Reactions of 1-Nitroso-1-phenyl-3-(4-pyridylmethyl)ureas

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概要

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• Treatment of 1-nitroso-1-phenyl- and 1-nitroso-1-(4-tolyl)-3-(4-pyridylmethyl)ureas (Ia, b) with methanol and ethanol at room temperature gave methyl and ethyl N-(4-pyridylmethyl)-carbamates (IIIa, b) in almost quantitative yields, together with benzene (IVa) and toluene (IVb), respectively. Treatment of Ia, b with benzene at 70℃ gave 4-pyridylmethylamine (V) with biphenyl (VIa) and its 4-methyl derivative (VIb), respectively. Treatment of Ia, b with sodium azide in aqueous acetone at -5℃ gave 1,3-bis(4-pyridylmethyl)urea (VII) and phenylazides (VIIIa, b) in more than 90% yields.Compound Ia showed antitumor activity against rat ascites hepatoma AH13,but not against mouse lymphoid leukemia L1210. The mechanisms of these reactions and the mechanism of antitumor action of Ia are discussed

• 公益社団法人日本薬学会の論文
• 1986-01-25

著者

• 宮原 誠

  National Institute of Hygienic Sciences, University of Tokyo

• 神谷 庄造

  National Institute of Hygienic Sciences, University of Tokyo

• 宮原 誠

  国立医薬品食品衛生研究所 食品部

• 宮原 美知子

  国立医薬品食品衛生研究所 衛生微生物部

• 宮原 誠

  National Institute Of Hygienic Sciences

• 宮原 美知子

  National Institute of Hygienic Sciences

• 神谷 庄造

  National Institute Of Hygienic Sciences

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