The C-Alkylaminomethylation of Pyridazinol N-Oxides. III. The Mannich Reaction of 5-Pyridazinol 1-Oxide

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概要

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• 5-Pyridazinol 1-oxide was synthesized from 5-methoxypyridazine 1-oxide which was obtained from 3,4-dichloro-5-methoxypyridazine 1-oxide. The Mannich reaction of 5-pyridazinol 1-oxide using 37% formalin and piperidine gave 6-piperidinomethyl-5-pyridazinol 1-oxide in 40% yield. Treatment of 5-pyridazinol 1-oxide with excess amounts of the reagents gave 4,6-di (piperidinomethyl)-5-pyridazinol 1-oxide in 56% yield. The alkylaminomethylated positions in these Mannich bases were determined by NMR spectroscopy.

• 公益社団法人日本薬学会の論文
• 1968-01-25

著者

• 神谷 庄造

  National Institute of Hygienic Sciences, University of Tokyo

• 大草 源三

  Showa College of Pharmaceutical Sciences

• 大草 源三

  Okusa Pharmaceutical Co. Ltd.

• 神谷 庄造

  National Institute Of Hygienic Sciences

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