Action Mechanism of Anti-AH13 Activity of 1,3-Diaryl-1-nitrosoureas and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Administration of 1,3-diaryl-1-nitrosoureas (I) prolonged the life span of rats inoculated intraperitoneally with ascites hepatoma AH13 cells. Active species produced from compound I were aryl diazonium ion, aryl isocyanate and nitrosonium ion. These species reacted with adenine, guanine, L-lysine, and the SH group of N-acetyl-DL-penicillamine. A possible anti-AH13 action mechanism of 1,3-diaryl-1-nitrosoureas in proposed to be as follows. The nitrosoureas (I) permeate quickly into the cytoplasm or nucleus, and decompose to give an active intermediate, an aryl diazonium ion, which reacts with nucleic acids of tumor cells to form a deoxyribonucleic acid (DNA) adduct, followed by tumor cell death. DNA repair of other damaged cells is inhibited by aryl isocyanate and nitrosonium ion liberated from compound I, which reacts with repair enzyme to form carbamoylated and S-nitrosated enzyme.
- 公益社団法人日本薬学会の論文
- 1984-02-25
著者
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宮原 誠
National Institute of Hygienic Sciences, University of Tokyo
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神谷 庄造
National Institute of Hygienic Sciences, University of Tokyo
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宮原 誠
国立医薬品食品衛生研究所 食品部
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宮原 美知子
国立医薬品食品衛生研究所 衛生微生物部
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宮原 誠
National Institute Of Hygienic Sciences
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宮原 美知子
National Institute of Hygienic Sciences
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神谷 庄造
National Institute Of Hygienic Sciences
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