Different Sensitivities of Rat Ascites Hepatoma AH13 and Mouse Lymphoid Leukemia L1210 Cells to Typical N-Nitrosoureas

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概要

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• Three structurally typical N-nitrosoureas showed different life-prolonging activities on animals bearing ascites hepatoma AH13 and lymphoid leukemia L1210 cells. 1-(2-Chloroethyl)-1-nitroso-3-(3-pyridylmethyl)urea N-oxide (CNPyUO) was highly effective against both AH13 and L1210,1,3-diphenyl-1-nitrosourea (DPhNU) was effective against AH13 but not against L1210,and 1-methyl-1-nitrosourea (MNU) was effective against L1210 but not against AH13.The cytostatic and deoxyribonucleic acid (DNA)-damaging activities of these N-nitrosoureas on both tumor cells in vivo or in vivo were studied. In the case of CNPyUO treatment in vivo, the formation of cross-linked DNA caused cell death of both tumor cells at 72h after treatment. DPhNU treatment rapidly caused scission of single-stranded DNA of the tumor cells, leading to cell death. MNU treatment caused scission of single-stranded DNA of both cells but showed cytostatic action only on L1210 cells.

• 公益社団法人日本薬学会の論文
• 1986-01-25

著者

• 神谷 庄造

  National Institute of Hygienic Sciences, University of Tokyo

• 宮原 美知子

  国立医薬品食品衛生研究所 衛生微生物部

• 宮原 美知子

  National Institute of Hygienic Sciences

• 末吉 祥子

  National Institute of Hygienic Sciences

• 神谷 庄造

  National Institute Of Hygienic Sciences

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