Preparation and Properties of 3-Alkyl-1-arylnitrosoureas and Related Compounds(Organic,Chemical)
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Nitrosation of 3-alkyl-1-arylureas was investigated with sodium nitrite in 99% formic acid or with isoamyl nitrite in chloroform. The preparation of 3-alkyl-1-aryl-1-nitrosoureas was effectively performed by using isoamyl nitrite in the absence of acids, since the 1-nitrosoureas were isomerized to the 3-nitroso isomers by acids. The carbon-13 nuclear magnetic resonance and infrared spectral properties of the products were examined and their structural features are discussed. It was found that 3-alkyl-1-aryl-1-nitrosoureas decomposed to form alkyl isocyanates and 3-alkyl-1-(2-nitroaryl) ureas in carbon tetrachloride. 1, 3-Rearrangement and transnitrosation also took place in this solvent.
- 公益社団法人日本薬学会の論文
- 1987-04-25
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