Syntheses of 1-Alkoxy-3,6-dimethyl-5-nitro-4 (1H)-pyridazinones and Related Compounds
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1-Alkoxy-3,6-dimethyl-5-nitro-4 (1H)-pyridazinones (VIIa, b) were synthesized by the nitration of 3,6-dimethyl-4-hydroxypyridazine 1-oxide (IV), followed by alkylation with alkyl halides. The catalytic hydrogenation of the nitro compound VIIa gave 1-methoxy-3,6-dimethyl-5-amino-4(1H)-pyridazinone (IX). 1-Methoxy-3,6-dimethyl-5-bromo-4 (1H)-pyridazinone (XI) was similarly synthesized by the bromination of IV, followed by alkylation.
- 公益社団法人日本薬学会の論文
- 1975-08-25
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