Degradation of 1,3-Diaryl-1-nitrosoureas in Aqueous Solutions and in Organic Solvents(Organic,Chemical)

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概要

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• The degradation of 1,3-di(p,p'-disubstituted)aryl-1-nitrosoureas (I) in aqueous buffer solutions (at 0℃ over pH -0.5 to 5.4) and in several organic solvents (benzene, chloroform, etc.) has been kinetically studied. In aqueous solution, the overall rates of degradation followed pseudo-first-order kinetics at constant pH. The decomposition reaction of 1,3-diphenyl-1-nitrosourea (Ia) was first-order in hydrogen ion over the pH range of -0.5 to 1.5 and denitrosated 1,3-diphenylurea (IIa) was formed predominantly. In the range of pH 1.5 to 5.4, the degradation of la was catalyzed by hydroxide ion and the main product was IIa, which was formed by the recombination of reactive products. In organic solvents, thermal degradation of la obeyed first-order kinetics and gave similar products to those yielded in the base-catalyzed degradation. The acid- and base-catalyzed and thermal degradations of Ia were about 10^2 to 10^3 times more rapid than those of related 1,3-dialkyl-1-nitrosoureas. The reaction mechanisms are discussed.

• 社団法人日本薬学会の論文
• 1987-11-25

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  National Institute Of Hygienic Sciences University Of Tokyo

• 宮原 誠

  National Institute of Hygienic Sciences, University of Tokyo

• 神谷 庄造

  National Institute of Hygienic Sciences, University of Tokyo

• 宮原 誠

  国立医薬品食品衛生研究所 食品部

• 宮原 誠

  National Institute Of Hygienic Sciences

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

• 神谷 庄造

  National Institute Of Hygienic Sciences

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