REVERSIBLE ELECTROCHEMICAL REDUCTION OF 1,6,6a-TRITHIA-3,4-DIAZA-PENTALENES TO THEIR ANION RADICALS WITH THE PRODUCTION OF SUPEROXIDE

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概要

• 論文の詳細を見る

• 1,6,6a-Trithia-3,4-diazapentalenes, which are hypervalent compounds, were reduced electrochemically and the resulting anion radicals reacted with dioxygen (O_2) to be re-oxidized to the starting materials, with the production of superoxide (O_2^<-・>). We have already reported that 1,6-dioxa-6a-thia-2,5-diazapentalenes mediate O_2^<-・> production in living cells and do serious damage to the cells. These results suggest that hypervalent heteropentalenes generally generate O_2^<-・> in the presence of O_2 by chemical or biological reduction system.

• 公益社団法人日本薬学会の論文
• 1991-07-25

著者

• 長野 哲雄

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 高橋 真木

  Faculty of Pharmaceutical Sciences, Univeristy of Tokyo

• 高橋 真木

  Faculty Of Pharmaceutical Sciences Univeristy Of Tokyo

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

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