INCREASING 5-LIPOXYGENASE INHIBITORY ACTIVITIES BY OXIDATIVE CONVERSION OF O-METHOXYPHENOLS TO CATECHOLS USING A Cu^<2+> - ASCORBIC ACID - O_2 SYSTEM

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概要

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• Several complicated o-methoxyphenols were oxidized with high selectivity to catechols by a Cu^<2+>- ascorbic acid-O_2 system. In this way, the RBL-1 5-lipoxygenase inhibitory activities of o-methoxyphenols were greatly invreased. [6]-Norgingerol (4), a novel compound derived from [6]-gingerol (3), shows promise as a lead compound for new drugs vecause of its high inhibitory potency (IC_<50>=5.0×10^<-8>M).

• 公益社団法人日本薬学会の論文
• 1990-03-25

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 樋口 恒彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 粟飯原 一弘

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 粟飯原 一弘

  東京大学薬学部

• 樋口 恒彦

  東京大学薬学部

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

• 樋口 恒彦

  Waseda Univ.

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