Effects of Methyl 9(or 10)-Hydroxy-10(or 9)-mercaptostearate and Hexanecabethioic S-Acid on Cupric Ion- or 2,2-Azo-bis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidation of Low Density Lipoprotein

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概要

• 論文の詳細を見る

• The preventive effects of two antioxidants, methyl 9(or 10)-hydroxy-10(or 9)-mercaptostearate (SH-S) and hexadecanethioic S-acid (thiopalmitic acid, SH-Pal) against the oxidative modification of low density lipoproteins (LDL) induced by cupric ion or a water soluble initiator of peroxyl radicals, 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH), were studied by measuring thiobarbituric acid-reactive substances (TBARS). SH-S acted as an effective antioxidant in the oxidative modification of LDL induced by either cupric ion or AAPH. Interestingly, SH-S completely inhibited the formation of fluorescence products and decreased both the fluorescence and α-tocopherol content in LDL induced by cupric ion, and reduced 1,1-diphenyl 2-picrylhydrazyl (DPPH) used as a stable free radical model. The antioxidative effect was effectively prevented by the addition of increasing amounts of N-ethylmalemide (NEM) to the system. SH-Pal also inhibited the cupric ion-induced LDL oxidation, but showed little inhibitory effect on the AAPH-induced LDL oxidation. Moreover, SH-Pal was reduced to palmitic acid during the AAPH-induced LDL oxidation.These findings indicate that SH-S protects against oxidative damage of LDL in vitro, and that it acts as a free radical in peroxidation. In addition, this study shows that SH-Pal doesn't act as an efficient antioxidant in AAPH-induced lipid peroxidation.

• 公益社団法人日本薬学会の論文
• 1996-05-15

著者

• 樋口 恒彦

  東京大学薬学部

• Tanaka M

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

• TOBINAGA Seisho

  Showa College of Pharmaceutical Sciences

• MURASE Masayuki

  Showa Pharmaceutical University

• Takada K

  Showa College Of Pharmaceutical Sciences

• TANAKA Mitsuo

  Showa College of Pharmaceutical Sciences

• TAKADA Kimihiko

  Showa College of Pharmaceutical Sciences

• HIGUCHI Toshiyuki

  Showa College of Pharmaceutical Sciences

• NAKAGAWA Mitsuo

  Showa College of Pharmaceutical Sciences

• Murase Masayuki

  Showa College Of Pharmaceutical Sciences

• HIGUCHI Teruhiko

  Neuropsychiatry Department, Showa University Fujigaoka Hospital

• Nakagawa M

  Showa College Of Pharmaceutical Sciences

• 樋口 恒彦

  Waseda Univ.

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