ヘム-チオレート酵素活性中心構造の特性探求と医薬化学への応用
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概要
著者
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樋口 恒彦
東京大学薬学部
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HIGUCHI Teruhiko
Neuropsychiatry Department, Showa University Fujigaoka Hospital
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樋口 恒彦
Waseda Univ.
関連論文
- ウサギ肝臓カルボニル還元酵素のアセトヘキサミドおよび4-アセチルピリジン誘導体に対する諸性質(発表論文抄録(1994))
- ウサギ腎由来のカルボニル還元酵素により触媒されるアセトヘキサミドの還元反応におけるケトン性薬物の抑制効果に関する研究
- Mechanism of Inhibition of Carbonyl Reductase from Rabbit Kidney by Phenylbutazone
- カルボニル還元酵素の単離およびその特性(発表論文抄録(1993))
- Further Studies on Reductive Metabolism of Acetohexamide in Heart
- Oxygen Activation by Iron(III)-Porphyrin/NaBH_4/Me_4N・OH System as Cytochrome P-450 Model. Oxygenation of Olefin, N-Dealkylation of Tertiary Amine, Oxidation of Sulfide, and Oxidative Cleavage of Ether Bond
- INCREASING 5-LIPOXYGENASE INHIBITORY ACTIVITIES BY OXIDATIVE CONVERSION OF O-METHOXYPHENOLS TO CATECHOLS USING A Cu^ - ASCORBIC ACID - O_2 SYSTEM
- 生体類似型酸化反応系「銅-アスコルビン酸-酸素」系 : フェノール・アニソール類の選択的酸化とその反応機構,および生理活性物質創製への応用
- Purifiation and Catalytic Properties of a Novel Acetohexamide-Reducing Enzyme from Rabbit Heart
- Stereoselective Reduction of Acetohexamide in Cytosol of Rabbit Liver
- Improved Nitric Oxide Detection Using 2,3-Diaminonaphthalene and Its Application to the Evaluation of Novel Nitric Oxide Synthase Inhibitors
- Superoxide Dismutase Activity of Iron(II)TPEN Complex and Its Derivatives
- Dipeptides Containing L-Arginine Analogs : New Isozyme-Selective Inhibitors of Nitric Oxide Synthase
- 錯体化学からNO合成酵素の配位構造と反応性の謎に迫る
- Selective Deoxygenation of Heteroaromatic N-Oxides with Olefins Catalyzed by Ruthenium Porphyrin
- 酵素機能に対するポルフィリン配位構造の必然性
- NO合成酵素とシトクロムP450 : その共通点と相違点
- Effects of Methyl 9(or 10)-Hydroxy-10(or 9)-mercaptostearate and Hexanecabethioic S-Acid on Cupric Ion- or 2,2-Azo-bis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidation of Low Density Lipoprotein
- Thiopalmitic Acid-Mediated Fe(III)-Nitrilotriacetate Reduction an Lipid Peroxidation
- シトクロムP450のO-O結合開裂機構をめぐる論争
- 含窒素芳香族複素環N-オキシドールテニウムポルフィリン触媒系による多様な高効率酸化反応
- 触媒補助基の多重導入によるチトクロムP-450モデルの高効率化
- A Novel Aromatic Hydroxylation of Phenolic Compounds with Cu^-Ascorbic Acid-O_2 System
- Application of Chemical P-450 Model Systems to Study Drug Metabolism. III. : Metabolism of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine
- "METABOLIC ACTIVATION" OF o-METHOXYPHENOLS VIA O-DEMETHYLATION WITH A Cu^ -ASCORBIC ACID-O_2 SYSTEM AS A FUNCTIONAL MODEL OF CYTOCHROME P-450
- FACILE PREPARATION OF UNSTABLE METABOLIC INTERMEDIATES : EPOXIDE(S) OF PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES BY THE CYTOCHROME P-450 CHEMICAL MODEL
- 60 2-オキサゾロンを構築材とする1、2-アミノアルコール類の効率合成(口頭発表の部)
- STUDIES ON BEFUNOLOL REDUCTASE FROM RABBIT LIVER
- 3-Alkoxycarbonyl-2-oxazolones and Their Homopolymers as Highly Preservable Amino-Protecting Reagents. tert-Butoxycarbonylation and Benzyloxycarbonylation of Amino Groups
- Optimum Conditions for the ^C-Phenylalanine Breath Test
- o_2-cu^-ASCORBIC ACID : A NOVEL OXIDATION SYSTEM FOR THE HIGHLY SELECTIVE O-CEALKYLATION OF 2-ALKOXYPHENOLS
- ヘム-チオレート酵素活性中心構造の特性探求と医薬化学への応用