Further Studies on Reductive Metabolism of Acetohexamide in Heart
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概要
- 論文の詳細を見る
Species and sex differences of acetohexamide reductase activity were investigated using the cytosolic fraction of haert homogenate. The activity in the rabbit was considerably higher than that in the other species (guinea pig, hamster, rat and mouse). No sex difference of the activity was observed in any of the species tested. Ketone-containing drugs (daunorubicin, befunolol and levobunolol) other than acetohexamide were little reduced in the cytosol of rabbit heart.Some aldehyde reductase inhibitors (phenobarbital, valproate and chlorothiazide) were found to decrease the acetohexamide reductase activity in the cytosol of rabbit heart.
- 社団法人日本薬学会の論文
- 1989-07-25
著者
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小田切 優樹
Faculty of Pharmaceutical Science, Kumamoto University
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今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
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今村 順茂
熊本大学薬学部
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今村 順茂
熊本大学大学院医学薬学研究部
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今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
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小嶋 祐一郎
Faculty of Pharmaceutical Sciences, Kumamoto University
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樋口 敏幸
Faculty of Pharmaceutical Sciences, Kumamoto University
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樋口 恒彦
東京大学薬学部
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小嶋 祐一郎
Faculty Of Pharmaceutical Sciences Kumamoto University
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Imamura Y
Kyoto Univ. Kyoto Jpn
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樋口 恒彦
Waseda Univ.
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樋口 敏幸
Faculty Of Pharmaceutical Sciences Kumamoto University
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