Improvement of Dissolution Characteristics and Chemical Stability of Prostaglandin E_1 by γ-Cyclodextrin Complexation
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概要
- 論文の詳細を見る
Inclusion complexation of prostaglandin E_1 (PGE_1) with γ-cyclodextrin (γ-CyD) in aqueous solution and in the solid phase was assessed by the solubility method, X-ray diffractometry, and thermal analysis. A solid complex of PGE_1-γ-CyD in a 1 : 2 molar ratio was obtained, and its dissolution behavior and chemical stability were examined. The dissolution rate of the γ-CyD complex was extremely large compared with that of PGE_1. In addition, the dehydration of PGE_1 to PGA_1 was significantly retarded by inclusion complex formation. The data suggest that γ-CyD complex may have great utility as a fast-dissolving form of PGE_1 with good storage properties.
- 公益社団法人日本薬学会の論文
- 1984-01-25
著者
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上釜 兼人
熊本大学 歯
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平山 文俊
Faculty Of Pharmaceutical Sciences Sojo University
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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小田切 優樹
Faculty of Pharmaceutical Science, Kumamoto University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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稲葉 光治
Research Institute Ono Phermaceutical Company
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藤瀬 昭彦
Faculty of Pharmaceutical Sciences, Kumamoto University
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稲葉 光治
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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Hirayama Fumitoshi
Faculty Of Pharmaceutical Sciences Sojo University
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藤瀬 昭彦
Faculty Of Pharmaceutical Sciences Kumamoto University
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