IMPROVING THE AQUEOUS STABILITY OF PROSTAGLANDIN E_2 AND PROSTAGLANDIN A_2 BY INCLUSION COMPLEXATION WITH METHYLATED-β-CYCLODEXTRINS
スポンサーリンク
概要
- 論文の詳細を見る
The effects of two methylated-β-cyclodextrins, heptakis (2,6-di-O-methyl)-β-cyclodextrin (DM-β-CyD) and heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CyD), on the dehydration rate of prostaglandin E_2 (PGE_2) and the isomerization rate of prostaglandin A_2 (PGA_2) in aqueous alkaline solution were investigated in comparison with natural β-cyclodextrin (β-CyD). In contrast to the acceleration effect of β-CyD, both DM-β-CyD and TM-β-CyD significantly retarded the reaction rates. The stabilizing effect of DM-β-CyD was larger than that of TM-β-CyD. Stability constants and rate constants of the complexes were kinetically determined on the basis of 1 : 1 inclusion complex formation. The data suggest that DM-β-CyD is useful in the stabilization of PGEs and PGAs in aqueous solution.
- 1984-10-25
著者
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上釜 兼人
熊本大学 歯
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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栗原 正日呼
Faculty of Pharmaceutical Sciences, Kumamato University
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Hirayama Fumitoshi
Faculty Of Pharmaceutical Sciences Sojo University
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上釜 兼人
崇城大 薬
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