シクロデキストリン包接によるチアムリン注射時の局所刺激性の改善
スポンサーリンク
概要
- 論文の詳細を見る
To reduce the local irritation induced by intramuscular injection of tiamulin (TM), the cyclodextrin complexation was utilized. The inclusion complexations of TM with three cyclodextrins (α-, β-, γ-CyD) in aqueous solution and in solid phase were assessed by ultraviolet, circular dichroism, solubility method, thermal analyses and powder X-ray diffractometry. Effects of CyDs on in vitro hemolysis induced by TM were investigated as a representation of local irritation. The protective effects of CyDs against hemolysis caused by TM increased in the order of γ->β->α-CyD. The irritative effects of TM and its γ-CyD complex on the M. vastus lateralis of rabbits were studied on gross examination. TM showed a distinct discoloration of M. vastus lateralis with surrounding hemorrhagic area. The irritation of γ-CyD complex was found to be milder than that of TM itself.
- 社団法人日本薬学会の論文
- 1982-09-25
著者
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入江 徹美
熊本大学薬学部医学薬学研究部薬剤情報分析学分野
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上釜 兼人
熊本大学薬学部
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入江 徹美
熊本大・薬
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小田切 優樹
熊本大学薬学部 薬剤学研究室
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上釜 兼人
熊本大学 歯
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佐藤 洋一
日本全薬工業株式会社中央研究所
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松丸 秀夫
日本全薬工業株式会社中央研究所
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入江 徹美
熊本大学薬剤情報分析学
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Irie T
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Irie Tetsumi
Dep. Of Clinical Chemistry And Informatics Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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上釜 兼人
崇城大 薬
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小田切 優樹
熊本大学薬学部
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