Determination of the Stability Constants for Inclusion Complexes of Cyclodextrins with Various Drug Molecules by High Performance Liquid Chromatography

概要

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Stability constant (K_e) for 1 : 1 inclusion complexes of α-and β-cyclodextrins with barbiturates, phenothiazines, sulfonylamides, and sulfonylureas were determined by high performance liquid chromatography (HPLC). The retention times of the drugs following the binding to cyclodextrins in aqueous mobile phase on ion exchange support were quantitatively treated to obtain the K_e values. The K_e values obtained by HPLC method were in fair agreement with those obtained by other methods such as solubility and spectroscopic methods. The advantages of HPLC method developed here were that K_e values could be rapidly obtained by simple procedure with minimum quantity of the drugs and reproducibility and accuracy were not less than other methods. Furthermore, this method was proved to be particularly suitable for chemically unstable compounds such as phenothiazines.
社団法人日本薬学会の論文
1978-11-25