Inclusion Complexation of β-Cyclodextrin with Some Sulfonamides in Aqueous Solution
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概要
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The interaction of β-cyclodextrin with some sulfonamides in aqueous solution has been investigated by circular dichroism, UV absorption, and solubility techniques. Solubility and spectral changes were quantitatively treated to obtain stoichiometric ratio, which was found to be 1 : 1,formation constants, and thermodynamic parameters for inclusion complexation. All results suggest that steric and hydrophobic factors of the drugs were largely responsible for this interaction.
- 公益社団法人日本薬学会の論文
- 1978-04-25
著者
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平山 文俊
Faculty Of Pharmaceutical Sciences Sojo University
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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池田 憲
名古屋市立大学薬学部
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池田 憲
Faculty Of Pharmaceutical Sciences Nagoya City University
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小田切 陽子
ファーマダイワ
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