胎盤移行したバルプロ酸の新生児期における消失半減期(1例報告)

概要

論文の詳細を見る
The pharmacokinetic parameters of valproic acid (VPA) transferred via the placenta were clinically investigated in a newborn infant born to an epileptic mother. The newborn, delivered at about 37-week gestation, was a healthy male (birth weight 2,500g). The Apgar score was 6. The serum levels of VPA between 6 hours and 8 days after birth were monitored by the FPIA method. The elimination pattern was mono-exponential, and the pharmacokinetic parameters were t1/2=45.7 hr and Kel=0.0152 hr^<-1> according to the one compartment model.
日本医療薬学会の論文
1986-08-20