カンプトテシン誘導体含有 Collagen-poly (Hydroxyethyl Methacrylate) Hydrogel 製剤の固形癌療法への応用

概要

論文の詳細を見る
Implantable collagen-poly (hydroxyethyl methacrylate (HEMA)) hydrogels containing antitumor drugs were prepared and evaluated for use in controlled drug carrier systems. The drugs used were CPT-11 and SN-38 which were derivatives of camptothecin (CPT). The drugs were released from the hydrogels at a constant rate (zero-order release) over about I week. The drugs sited in the plasma of mice were detectable for 5 days after subcutaneous injjection of the hydrogels while they were undetectable at 24 hours after the injection of the drug aqueous solutions. Ehrlich solid tumor was developed by subcutaneous inoculation of the tumor-cell suspension in the inguinal region of mice. The hydrogels demonstrated greatly improved antitumor activity over the drug aquenus solutions as evidenced by the gross tumor weight and the survival time assessments. This was attributed to the controlled and slow release of the drugs from the gels.
日本医療薬学会の論文
1994-02-20