The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media, VI. : Hydrogen Exchange Reaction and Proton and Carbon-13 Nuclear Magnetic Resonance Spectra of Estazolam

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概要

• 論文の詳細を見る

• Estazolam deuterated in the triazole ring was isolated and its carbon-13 nuclear magnetic resonance signals were assigned in relation to those of estazolam. The coupling constant ratio, [numerical formula], for the triazole C-1 atom was 6.66. Rates of hydrogen exchange of estazolam with deuterium were measured at 23℃ in acidic aqueous solution (0.5 N DCl) and in methanol-d_4 contaning trifluoroacetic acid-d and triethylamine. The exchange reaction was accelerated in the presence of acid or base, indicating that the exchange occurs in a base-catalyzed reaction and that the triazole C-1 atom of estazolam behaves as an acid.

• 公益社団法人日本薬学会の論文
• 1986-07-25

著者

• 黒野 幸久

  神戸大学 大学院医学系研究科精神神経科学分野

• 池田 憲

  名古屋市立大学薬学部

• 池田 憲

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 八代 有

  Faculty of Pharmaceutical Sciences Nagoya City University

• 八代 有

  名古屋市立大学薬学部

• 黒野 幸久

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 桑山 知成

  Pharmacy, NTT Tokai General Hospital

• 桑山 知成

  Pharmacy Ntt Tokai General Hospital

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