The Interactions of Prostaglandins E_1,E_2 and F_<2a> with Lauromacrogol

概要

論文の詳細を見る
The interaction of unionized and ionized species of prostaglandins (PGE_1,PGE_2 and PGF_<2a>) with lauromacrogols was studied by equilibrium dialysis and potentiometric titration. The magnitude of interaction was analyzed in terms of the partition coefficient (P), moles of drug bound per mole of surfactant (K) and moles of drug bound per micelle (K'). The order of the interaction constants with lauromacrogol containing 23 mol of ethylene oxide was PGE_1>PGE_2>PGF_<2a>, which corresponds to the order of their partition coefficients between water and cyclohexane. The effect of oxyethylene chain length on the interaction was examined with PGE_1 and PGF_<2a>. Regardless of species, the K value increased with increasing oxyethylene chain length. The P and K' values decreased with increasingly hydrophilic micellar phase. This is due to an increase of the partial molar volume and a reduced aggregation number, leading to an increase of micellar concentration with increasing oxyethylene chain length. The measures of the degree of interaction are desired to be closely related to the changes of physicochemical characteristics of micelles, i.e., to the amounts of drugs in the hydrophobic and hydrophilic regions available for drug binding.
公益社団法人日本薬学会の論文
1980-06-25