UTILIZATION OF HUMAN SERUM ALBUMIN AS DRUG ADDITIVES I. STABILIZER OF PROSTACYCLIN
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概要
- 論文の詳細を見る
To examine the possibility of using human serum albumin (HSA) as a new drug additive, the stability of prostacyclin (PGI_2) in the presence of HSA was investigated kinetically in pH 7.35 phosphate buffer at 25℃. The half-life for the hydrolysis of PGI_2 was prolonged 10-fold in the presence of about 4-fold HSA molar concentration. By displacement examination using clofibric acid and phenylbutazone, the effective site on HSA for the PGI_2 stabilization was found to be near tyrosine 411 of the HSA amino acid sequence, not near tryptophan 214 as supposed in the literature.
- 公益社団法人日本薬学会の論文
- 1982-07-25
著者
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黒野 幸久
神戸大学 大学院医学系研究科精神神経科学分野
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池田 憲
名古屋市立大学薬学部
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池田 憲
Faculty Of Pharmaceutical Sciences Nagoya City University
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黒野 幸久
Faculty of Pharmaceutical Sciences, Nagoya City University
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太田 直子
Faculty Of Pharmaceutical Sciences Nagoya City University
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