Effects of Monovalent Metal Ions and Propranolol on the Calcium Association in Calcium-Induced Alginate Gel Beads

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of monovalent metal ions (K^+ and Na^+) and propranolol (pK_a=9.45,a model cationic drug) on the calcium association in calcium-induced alginate gel beads and on the size changes of the beads were investigated. While calcium ions are an essential component for the gelation of alginate, the associated calcium was discharged by coexisting ionic substances such as the species above without the beads being disintegrated in water and buffers at pHs less than 4.0. The following became evident : (1)the accosiated calcium was completely discharged at pH 1.0 resulting in contractin of the bead body to about half, (2) at pH 4.0 about 75% of the calcium was lost and the bead volume was greatly reduced as the drug loading increased, (3) the calcium-discharge action was comparable among the above sucstances, (4) however, the monovalent metal ions brought about expansion of the beads while the drug resulted in contraction of the neads, depending on the bulk concentraion of the drug.

• 公益社団法人日本薬学会の論文
• 1990-11-25

著者

• 池田 憲

  名古屋市立大学薬学部

• 池田 憲

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 四ツ柳 智久

  名古屋市立大学 薬

• 四ツ柳 智久

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 吉岡 勇

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 瀬木 直樹

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 瀬木 直樹

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 吉岡 勇

  Faculty Of Pharmaceutical Sciences Nagoya City University

関連論文

• Blister Package,いわゆるPress Through Package(PTP)が食道異物として処置された症例の統計的文献考察
• カンプトテシン誘導体含有 Collagen-poly (Hydroxyethyl Methacrylate) Hydrogel 製剤の固形癌療法への応用
• Kinetics and Mechanism of Tautomerism of a Hydroxy Schiff Base, N-[2-{2-Hydroxyethylimino(methyl)methyl}phenyl]-2-chlorpropamide, in Solution
• カンプトテシン誘導体とヒト血漿タンパクとの相互作用
• 講座名あれこれ
• Kinetics and Mechanism of the Acid-Base Equilibrium and the Hydrolysis of Benzodiazepinooxaziines
• 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第16報)Nuclear Magnetic Resonanceシフト試薬を利用したベンゾジアゼピノオキサゾール誘導体のcis/trans異性体の存在比率の算出
• The Crystal and Molecular Structure of Racemic 11b-Methylbenzodiazepinooxazole
• Stability of Forskolin in Lipid Emulsions and Oil/Water Partition Coefficients
• Effect of Glycyrrhizinate on Dissolution Behavior and Rectal Absorption of Amphotericin B in Rabbits
• Reaction between Salicylic Acid and Zinc Oxide in the Presence of Water.
• Esterase-like Activity of Human Serum Albumin. VII. Reaction with p-Nitrophenyl 4-Guanidino-benzoate
• Effects of Drug Bindings on the Esterase-like Activity of Human Serum Albumin. VII. Subdivision of R-Type Drugs Inhibiting the Activity towards p-Nitrophenyl Acetate(Pharmaceutical)
• Esterase-like Activity of Human Serum Albumin. IV. Reactions with Substituted Aspirins and 5-Nitrosalicyl Esters
• Effects of Drug Binding on the Esterase-Like Activity of Human Serum Albumin. V. Reactive Site towards Substituted Aspirins
• 酸性溶液中でのフェノチアジン系トランキライザーのラウロマクロゴールミセルへの取り込み(発表論文抄録(1984年),福山大学開学10周年記念号)
• Uptake of Phenothiazine Tranquilizers by Lauromacrogol Micelles in Acidic Solution
• 胎盤移行したバルプロ酸の新生児期における消失半減期(1例報告)
• Bile Salt-Induced Disintegration of Egg Phosphatidylcholine Liposomes : A Kinetic Study Based on Turbidity Changes
• A Two-Step Model of Disintegration Kinetics of Liposomes in Bile Salts
• Acid-Induced and Calcium-Induced Gelation of Alginic Acid : Bead Formation and pH-Dependent Swelling
• Effects of Monovalent Metal Ions and Propranolol on the Calcium Association in Calcium-Induced Alginate Gel Beads
• Complex Formation between Gallium(III) and Agriamycin in Aqueous Solutions
• Interaction of Calcium-Induced Alginate Gel Beads with Propranolol
• Micelle-Mediated Transport of Vitamin K_1 through Porous Membranes : Contribution of Phosphatidylcholine-Bile Salt Mixed Micelles
• Degradation of 4'-Methylumbelliferyl 4-Guanidinobenzoate Catalyzed by Human Serum Albumin
• pH-Dependent Degradation and Stabilization of Meclofenoxate Hydrochloride by Human Serum Albumin
• NaCl-INDUCED AGGREGATION OF EGG PHOSPHATIDYLCHOLINE LIPOSOMES
• The Rabbit as an Animal Model for Warfarin-Induced Hypoprothrombinemia : The Relationship between Prothrombin Time and Prothrombin Complex Activity
• The Interactions of Prostaglandins E_1,E_2 and F_ with Lauromacrogol
• Esterase-Like Activity of Human Serum Albumin. VIII. Reaction with Amino Acid p-Nitrophenyl Esters
• 溶液製剤における分子間相互作用 : 薬物の溶解性の向上, 分配並びに安定性
• Multiple and Irreversible Binding of cis-Diamminedichloroplatinum(II) to Human Serum Albumin and Its Effect on Warfarin Binding
• 日本薬学会教育賞受賞 手島節三氏の業績
• 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第15報)11bメチル置換ベンゾジアゼピノオキサゾール系化合物のプロトン交換反応におけるイミニウム型構造の寄与
• Kinetics and Mechanism of the Acid-Base Equilibrium and the Subsequent Hydrolysis of 11b-Hydrogenbenzodiazepinooxazoles
• cis/trans Isomerization Rate of Oxazolam in Organic Solvents Measured by High-Performance Liquid Chromatography
• 枯草菌芽胞の発芽に対するフェノール類および脂肪酸類の定量的構造発芽阻止活性相関
• Solubilization of Steroid Hormones by Polyoxyethylene Lauryl Ether
• Solubilization of Benzoic Acid Derivatives by Polyoxyethylene Lauryl Ether
• Effect of Micellar Interactions on Base-Catalyzed Hydrolysis of Procaine
• Micellar Interaction of Tetracycline Antibiotics
• UTILIZATION OF HUMAN SERUM ALBUMIN AS DRUG ADDITIVES I. STABILIZER OF PROSTACYCLIN
• Effects of Drug Binding on the Esterase-Like Activity of Human Serum Albumin. III. : Evaluation of Reactivities of the Two Active Sites by Using Clofibric Acid as an Inhibitor
• 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第12報) : 11bメチル置換ベンゾジアゼピノオキサゾール系化合物のプロトン交換反応
• Kinetics and Mechanism of Reversible Hydrolysis of 11b-Methylbenzodiazepinooxazoles
• Kinetics and Mechanism of the Acid-Base Equilibrium of Benzodiazeinooxazoles : Oxazolam Analogs
• フェノチアジン系薬物とアルキルスルホン酸とのイオン対形成およびアルコール溶媒和
• Hydrolysis Rate of Ethyl Cinnamates in the Presence of Cyclodextrin
• Inclusion Complexes of Cinnamic Acids with Cyclodextrins. Mode of Inclusion in Aqueous Solution
• Esterase-like Activity of Human Serum Albumin. V. Reaction with 2,4-Dinitrophenyl Diethyl Phosphate
• Ion Pair Formation of Tetracyclines-Haloacetates and Alcohol Solvation
• Inclusion Complexation of β-Cyclodextrin with Some Sulfonamides in Aqueous Solution
• Calcium-Induced Gelation of Alginic Acid and pH-Sensitive Reswelling of Dried Gels(Pharmaceutical)
• Effect of Cholesterol on Liposome Stability to Ultrasonic Disintegration and Sodium Cholate Solubilization(Pharmaceutical)
• Effects of Drug Binding on the Esterase Activity of Human Serum Albumin : Inhibition Modes and Binding Sites of Anionic Drugs
• Esterase-Like Activity of Human Serum Albumin : Structure-Activity Relationships for the Reactions with Phenyl Acetates and p-Nitrophenyl Esters
• Reactions of Phenyl Salicylates with Cyclodextrin in Alkaline Solution
• Effects of Drug Bindings on Esterase Activity of Human Serum Albumin. Dissociation Constants of the Complexes between the Protein and Drugs such as N-Arylanthranilic Acids, Coumarin Derivatives and Prostaglandins
• Methanesulfonic Acid Derivative of N-Alkyl Aniline : Basicity of Aniline and Reactivity
• Simultaneous Determination of Complexation Equilibrium Constants for Conjugated Guest Species by Extended Potentiometric Titration Method : On Barbiturate-β-Cyclodextrin System
• Inclusion Complexation of Barbiturates with β-Cyclodextrin in Aqueous Solution. I. Spectroscopic Study on the Mode of Interaction
• Esterase-like Activity of Human Serum Albumin. VI. : Reaction with p-Nitrophenyl Glycinate
• Photo-Stabilization and Solubilization of an Aldose Reductase Inhibitor, (E)-3-Carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine(ONO-2235), by Human Serum Albumin(Pharmaceutical)
• Studies on Decomposition and Stabilization of Drugs in Solution. I. Chemical Kinetic Studies on Aqueous Solution of Phenobarbital.
• Effects of Drug Binding on the Esterase-like Activity of Human Serum Albumin. VI. Reaction with Di-p-nitrophenyl Adipate
• The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media, VI. : Hydrogen Exchange Reaction and Proton and Carbon-13 Nuclear Magnetic Resonance Spectra of Estazolam
• The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media. V. : Kinetics of Hydrolysis of Flutazolam and Haloxazolam in Aqueous Solution
• The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media. II. Kinetics and Mechanism of the Acid-Base Equilibrium Reaction of Oxazolam
• Methanesulfonic Acid Derivative of Drug. I. Reversible Hydrolysis Rate of Methanesulfonic Acid Derivative of Substituted Aniline and Biopharmaceutical Study on Sodium p-Phenetidinomethanesulfonate
• ヒト血清アルブミンの酵素的活性と薬物結合
• Electronic Properties of N-Heteroaromatics. XII. On the Mode of Interaction between Theophylline and Ethylenediamine in Aqueous Solution.
• Methanesulfonic Acid Derivative of Sulfonamide. II. Successively Reversible Hydrolysis of Sulfisoxazole Derivative
• Methanesulfonic Acid Derivative of Sulfonamides. I. Hydrolysis Rate in Vitro and Pharmacokinetics in Vivo
• Solubilization of Barbiturates by Polyoxyethylene Lauryl Ether
• Studies on Decomposition and Stabilization of Drugs in Solution. V. Stabilization of Barbiturate in Aqueous Solution of Polyalcohols and Sugars
• Studies on Decomposition and Stabilization of Drugs in Solution. IV. Effect of Dielectric Constant on the Stabilization of Barbiturate in Alcohol-Water Mixtures
• Kinetics and Mechanism of Transamination of Thiamine in the Presence of Bisulfite
• アメリカ薬学会のAcademy of Pharmaceutical Sciences第31回年会
• Effects of Drug Binding on the Esterase-Like Activity of Human Serum Albumin. IV. Application of an Analog Computer to Determination of the Multiple Dissociation Constants
• Release Rates of Substituted Aniline from Its Methanesulfonic Acid Derivative in Acid Region
• Effect of ortho-Substituents on Methanesulfonic Acid Derivative of Substituted Aniline
• Methanesulfonic Acid Derivative of p, p'-Diaminodiphenylsulfone. II. Pharmacokinetics and Availability of Parental Drug in Rabbit
• Methanesulfonic Acid Derivative of p, p'-Diaminodiphenylsulfone. I. Hydrolysis Rate in Vitro

もっと見る 閉じる

スポンサーリンク