Micellar Interaction of Tetracycline Antibiotics

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概要

• 論文の詳細を見る

• Micellar interactions of tetracycline, oxytetracycline, chlortetracycline and minocycline were examined in aqueous solutions of polyoxyethylene lauryl ether (PLE), sodium lauryl sulfate (SLS) and dodecyltrimethylammonium chloride (DTAC) at various pHs (2.1-5.6) by dynamic dialysis. The respective partition coefficients of ionized and zwitterionic species were calculated. The ionized species of the antibiotics except for minocycline were more solubilized than zwitterionic ones in PLE solution, in which the orientation of hydrophobic parts of the antibiotic and micelle structures plays a primary mechanism for their interaction. In ionic surfactant solutions, the electrostatic force was predominant at lower pH and the solubilization capability of the anionic surfactant was much higher than that of the cationic one for tetracycline over the pH range examined.

• 公益社団法人日本薬学会の論文
• 1977-05-25

著者

• 池田 憲

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 冨田 久夫

  福山大学薬学部

• 富田 久夫

  福山大学

• 四柳 智久

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 四柳 智久

  Faculty Of Pharmaceutical Sciences Nagoya City University

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