Studies on Decomposition and Stabilization of Drugs in Solution. V. Stabilization of Barbiturate in Aqueous Solution of Polyalcohols and Sugars

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Subsequent to the previous work, the stabilizing effect of polyhydric alcohols and sugars on the alkaline degradation of methylhexabital J. P. (hexobarbital I. P.) was studied with respect to dielectric constant of the medium and following conclusions were drawn : 1) The magnitude of retardation of the reaction rate by ethylene glycol and glycerol was as large as or slightly larger than that by alcohols, but activation energy markedly decreased as the dielectric constant decreased. This proves that the stabilizing activity of these substances cannot be attributed only to the decrease of dielectric constant of the medium. 2) Sugars retarded degradation much more than was expected from the change of dielectric constant. The effect of glucose was particularly distinct. 3) The retardation of degradation by polyhydric alcohols and sugars would be attributed to the binding of hydroxyl ion to metal complex ion consisting of alkaline metal ion, hydroxyl ion, and polyhydric alcohol or sugar. Distinct retardation by glucose may be attributed to its relatively large value of pK.
公益社団法人日本薬学会の論文
1960-06-25