Micelle-Mediated Transport of Vitamin K_1 through Porous Membranes : Contribution of Phosphatidylcholine-Bile Salt Mixed Micelles

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概要

• 論文の詳細を見る

• Diffusion of vitamin K_1 solubilized by phosphatidylcholine-sodium deoxycholate mixed micelles through porous membranes having various pore characterisitcs was examined. The membranes include Nuclepore, Duragard and nitrocellulose membranes, which were intended to mimic the narrow channels in the vicinity of absorptive brush border. The diffusino coefficient of the mixed micelles was 4.6-5.5×10^<-7> cm^2/s, from which the hydrodynamic radius was calculated to be about 50Å. The dependence of the diffusivity on pore size showed that the transport of the micelles is hindered by pores having a radus ratio of the diffusate to the pore of about 0.05 or larger.

• 公益社団法人日本薬学会の論文
• 1989-09-25

著者

• 池田 憲

  名古屋市立大学薬学部

• 池田 憲

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 四ツ柳 智久

  名古屋市立大学 薬

• 四ツ柳 智久

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 永田 マリ子

  名古屋市立大学・薬

• 永田 マリ子

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 永田 マリ子

  名古屋市立大学病院薬剤部

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