Methanesulfonic Acid Derivative of p, p'-Diaminodiphenylsulfone. II. Pharmacokinetics and Availability of Parental Drug in Rabbit
スポンサーリンク
概要
- 論文の詳細を見る
Pharmacokinetic studies on various methanesulfonic acid derivatives of p, p'-diamino-diphenylsulfone (Da) were carried out on rabbit and the liberation of parental Da was pursued. The general formula of the studied derivatives is NaO_3SHC__RHN-C_6H_4-SO_2-C_6H_4-NHC__RHSO_3Na, where R are H-, CH_3-, HOCH_2 (CHOH)_4-(promin) and C_6H_5-. The time courses of the blood concentration for all the derivatives and parental Da administered intravenously were represented in biexponential equations. The elimination rates of the water-soluble derivatives were about 10-fold larger than that of parental Da. The distribution volume of central compartment for Da was larger than those of the derivatives. No detectable amount of Da was found in blood after the i. v. administrations of promin and the derivative of R=H. From the viewpoint of drug availability, the area under liberated Da vs. time curve was compared to that of intact Da and deconvolution calculation was also carried out.
- 公益社団法人日本薬学会の論文
- 1974-06-25
著者
-
黒野 幸久
神戸大学 大学院医学系研究科精神神経科学分野
-
上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
-
池田 憲
Faculty Of Pharmaceutical Sciences Nagoya City University
-
黒野 幸久
Faculty of Pharmaceutical Sciences, Nagoya City University
関連論文
- Involvement of Lipid Rafts of Rabbit Red Blood Cells in Morphological Changes Induced by Methylated β-Cyclodextrins(Biopharmacy)
- Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with γ-Cyclodextrin Formed by Solubility Method
- Improved Stability of OPALMON^[○!R] Tablets under Humid Conditions IV : Effect of Polysaccharides and Disintegrants on the Stability and Dissolution Property of OPALMON^[○!R] Tablets
- Improvement of Dissolution Properties of a New Helicobacter pylori Eradicating Agent (TG44) by Inclusion Complexation with β-Cyclodextrin
- Improvement of Solubility and Oral Bioavailability of 2-(N-Cyanoimino)-5-{(E)-4-styrylbenzylidene}-4-oxothiazolidine (FPFS-410) with Antidiabetic and Lipid-Lowering Activities in Dogs by 2-Hydroxypropyl-β-cyclodextrin
- Preparation and Pharmaceutical Evaluation of Liposomes Entrapping Salicylic Acid/γ-Cyclodextrin Conjugate
- Enhancing Effects of Galactosylated Dendrimer/α-Cyclodextrin Conjugates on Gene Transfer Efficiency(Biopharmacy)
- Effects of Cyclodextrins on the Aggregation of Recombinant Human Growth Hormone (rhGH)
- A Moderate Interaction of Maltosyl-α-cyclodextrin with Caco-2 Cells in Comparison with the Parent Cyclodextrin
- Analysis of the Phase Solubility Diagram of a Phenacetin/Competitor/β-Cyclodextrin Ternary System, Involving Competitive Inclusion Complexation
- Hydrolysis Behavior of Prednisolone 21-Hemisuccinate/β-Cyclodextrin Amide Conjugate : Involvement of Intramolecular Catalysis of Amide Group in Drug Release
- Effects of Aging on Crystallization, Dissolution and Absorption Characteristics of Amorphous Tolbutamide-2-Hydroxypropyl-β-cyclodextrin Complex
- Inhibitory Effect of 2-Hydroxypropyl-β-cyclodextrin on the Foaming Generated by the Phosphodiester Compound of Vitamin C and E, EPC-K1
- Enhanced Absorption of Cyclosporin A be Complexation with Dimethyl-β-cyclodextrin in Bile Duct-Cannulated and -Noncannulated Rats
- シクロデキストリン polypseudorotaxane によるPEG化タンパク質持続放出システムの構築
- 抗ヒスタミン薬とシクロデキストリンの相互作用ならびに苦味軽減効果
- ジメチルアセチル-β-シクロデキストリンによるエンドトキシンショック抑制作用
- 薬物/シクロデキストリン結合体封入リポソームによる薬物の体内動態の制御
- 糖修飾デンドリマー/シクロデキストリン結合体を用いた細胞特異的遺伝子デリバリー
- ジメチル-β-シクロデキストリンによる薬物排出ポンプの機能阻害におけるCaveolaeの関与
- シクロデキストリン結合体を利用したケトプロフェンの経口持続性製剤の設計
- ジメチル-β-シクロデキストリンによるP-糖タンパク質の機能阻害におけるCaveolaeの関与
- 薬物/シクロデキストリン複合体封入リポソームの薬物送達システムへの応用
- シクロデキストリン誘導体によるマクロファージからのNO産生の抑制効果
- 遅延放出製剤の設計における薬物/シクロデキストリン結合体の有効利用
- エチルセルロース固体分散体からのメトプロロール放出に及ぼす2-ヒドロキシプロピル-β-シクロデキストリンの影響
- 遺伝子組換えヒト成長ホルモンの凝集反応に及ぼす親水性シクロデキストリンの影響
- Varying Effects of Cyclodextrin Derivatives on Aggregation and Thermal Behavior of Insulin in Aqueous Solution
- Spectroscopic Characterization of the Inclusion Complex of a Luteinizing Hormone-Releasing Hormone Agonist, Buserelin Acetate, with Dimethyl-β-cyclodextriin
- 脂肪酸/シクロデキストリン併用系によるプロスタサイクリン誘導体ベラプロストの経皮吸収の制御
- Enhanced Nasal Delivery of Luteinizing Hormone Releasing Hormone Agonist Buserelin by Oleic Acid Solubilized and Stabilized in Hydroxypropyl-β-cyclodextrin
- Characterization of the Inclusion Mode of β-Cyclodextrin Sulfate and Its Effect on the Chlorpromazine-Induced Hemolysis of Rabbit Erighrocytes
- Stabilization of Prostaglandin E_1 in Fatty Alcohol Propylene Glycol Ointment by Acidic Cyclodextrin Derivative, O-Carboxymethyl-O-ethyl-β-cyclodextrin
- Utility of 2-Hydroxypropyl-β-cyclodextrin in an Intramuscular Injectable Preparation of Nimodipine
- Some Pharmaceutical Properties of 3-Hydroxypropyl- and 2,3-Dihydroxypropyl-β-cyclodextrins and Their Solubilizing and Stabilizing Abilities
- Improvement in Percutaneous Absorption of Prednisolone by β- and γ-Cyclodextrin Complexations(Pharmaceutical)
- ALLEVIATION OF PROCHLORPERAZINE-INDUCED PRIMARY IRRITATION OF SKIN BY CYCLODEXTRIN COMPLEXATION
- Riboflavin-Sensitized Photooxidation of Phenothiazines in Aqueous Solution by Laser-Irradiation
- Determination of the Stability Constants for Inclusion Complexes of Cyclodextrins with Various Drug Molecules by High Performance Liquid Chromatography
- トリバレリル化β-シクロデキストリン膜を用いた水溶性薬物の放出制御
- 各種シクロデキストリンによるシクロスポリンAの消化管吸収およびリンパ移行の改善
- 阪神淡路大震災と神戸市における自殺の動向 (特集 第42回精神保健シンポジウム(神戸)自殺予防を考える)
- RT-PCR法を用いた脳組織からの麻疹ウイルスの検出
- カンプトテシン誘導体含有 Collagen-poly (Hydroxyethyl Methacrylate) Hydrogel 製剤の固形癌療法への応用
- Kinetics and Mechanism of Tautomerism of a Hydroxy Schiff Base, N-[2-{2-Hydroxyethylimino(methyl)methyl}phenyl]-2-chlorpropamide, in Solution
- カンプトテシン誘導体とヒト血漿タンパクとの相互作用
- Regiospecific Nitration of Quinoline and isoquinoline through the Reissert Compounds
- ニルバジピン一水和物の結晶構造と多形転移挙動
- 高機能性シクロデキストリンの医薬への応用(魅惑の超分子ワールド)
- Inclusion Mode of Flurbiprofen with β-Cyclodextrin and Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, and Improvements of Some Pharmaceutical Properties of Flurbiprofen by Complexation
- Inclusion Complex of Acetohexamide with β-Cyclodextrin and Its Hypoglycemic Activity in Rabbit
- Kinetics and Mechanism of the Acid-Base Equilibrium and the Hydrolysis of Benzodiazepinooxaziines
- 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第16報)Nuclear Magnetic Resonanceシフト試薬を利用したベンゾジアゼピノオキサゾール誘導体のcis/trans異性体の存在比率の算出
- Reissert-Type Reaction of N-Sulfonyl- or N-Acyl-phthalazinimum Salts with Trimethyl Phosphite and Crystal Structure of Dimethyl 2-Mesyl-1,2-dihydro-1-phthalazinylphosphonate
- The Crystal and Molecular Structure of Racemic 11b-Methylbenzodiazepinooxazole
- Preparation of Hydrophilic Nanoparticles of C_ with High Resistance to Aggregation during Storage, using 2-Hydroxypropyl-β-cyclodextrin
- Prominent Inhibitory Effect of 2-Hydroxybutyl-β-cyclodextrin on Solution-mediated Polymorphic Transition of Chlorpropamide
- Esterase-like Activity of Human Serum Albumin. VII. Reaction with p-Nitrophenyl 4-Guanidino-benzoate
- Effects of Cyclodextrins on Degradations of Emetine and Cephaeline in Aqueous Solution
- Interaction of the Fluorescent Probe 7-Anilino-4-methylcoumarin-3-acetic Acid with α-Globulin
- Interaction between Methacycline and Human Serum Albumin
- Effects of Drug Bindings on the Esterase-like Activity of Human Serum Albumin. VII. Subdivision of R-Type Drugs Inhibiting the Activity towards p-Nitrophenyl Acetate(Pharmaceutical)
- Esterase-like Activity of Human Serum Albumin. IV. Reactions with Substituted Aspirins and 5-Nitrosalicyl Esters
- Effects of Drug Binding on the Esterase-Like Activity of Human Serum Albumin. V. Reactive Site towards Substituted Aspirins
- X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE ABSOLUTE CONFIGURATION OF (+) FLURBIPROFEN UTILIZING β-CYCLODEXTRIN COMPLEXATION
- Synthesis of 10-Arylpyrimido [4,5-b] quinoline-2,4 (3H, 10H) diones (10-Aryl-5-deazaflavins) and Their Use in Oxidations of Alcohols and Amines
- Transparent, Adhesive Film Formation of Per-O-valeryl-β-cyclodextrin
- Inclusion Complexation of p-Hydroxybenzoic Acid Esters with 2-Hydroxypropyl-β-cyclodextrins. On Changes in Solubility and Antimicrobial Activity
- Enhancement of Oral Bioavailability of Spironolactone by β- and γ-Cyclodextrin Complexations
- Esterase-Like Activity of Human Serum Albumin. VIII. Reaction with Amino Acid p-Nitrophenyl Esters
- 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第15報)11bメチル置換ベンゾジアゼピノオキサゾール系化合物のプロトン交換反応におけるイミニウム型構造の寄与
- Kinetics and Mechanism of the Acid-Base Equilibrium and the Subsequent Hydrolysis of 11b-Hydrogenbenzodiazepinooxazoles
- cis/trans Isomerization Rate of Oxazolam in Organic Solvents Measured by High-Performance Liquid Chromatography
- UTILIZATION OF HUMAN SERUM ALBUMIN AS DRUG ADDITIVES I. STABILIZER OF PROSTACYCLIN
- Effects of Drug Binding on the Esterase-Like Activity of Human Serum Albumin. III. : Evaluation of Reactivities of the Two Active Sites by Using Clofibric Acid as an Inhibitor
- Improvement of Dissolution Characteristics and Chemical Stability of Prostaglandin E_1 by γ-Cyclodextrin Complexation
- 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第12報) : 11bメチル置換ベンゾジアゼピノオキサゾール系化合物のプロトン交換反応
- Kinetics and Mechanism of Reversible Hydrolysis of 11b-Methylbenzodiazepinooxazoles
- Kinetics and Mechanism of the Acid-Base Equilibrium of Benzodiazeinooxazoles : Oxazolam Analogs
- Esterase-like Activity of Human Serum Albumin. V. Reaction with 2,4-Dinitrophenyl Diethyl Phosphate
- Effects of Drug Binding on the Esterase Activity of Human Serum Albumin : Inhibition Modes and Binding Sites of Anionic Drugs
- Esterase-Like Activity of Human Serum Albumin : Structure-Activity Relationships for the Reactions with Phenyl Acetates and p-Nitrophenyl Esters
- Reactions of Phenyl Salicylates with Cyclodextrin in Alkaline Solution
- Effects of Drug Bindings on Esterase Activity of Human Serum Albumin. Dissociation Constants of the Complexes between the Protein and Drugs such as N-Arylanthranilic Acids, Coumarin Derivatives and Prostaglandins
- Methanesulfonic Acid Derivative of N-Alkyl Aniline : Basicity of Aniline and Reactivity
- Simultaneous Determination of Complexation Equilibrium Constants for Conjugated Guest Species by Extended Potentiometric Titration Method : On Barbiturate-β-Cyclodextrin System
- Esterase-like Activity of Human Serum Albumin. VI. : Reaction with p-Nitrophenyl Glycinate
- Photo-Stabilization and Solubilization of an Aldose Reductase Inhibitor, (E)-3-Carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine(ONO-2235), by Human Serum Albumin(Pharmaceutical)
- Effects of Drug Binding on the Esterase-like Activity of Human Serum Albumin. VI. Reaction with Di-p-nitrophenyl Adipate
- The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media, VI. : Hydrogen Exchange Reaction and Proton and Carbon-13 Nuclear Magnetic Resonance Spectra of Estazolam
- The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media. V. : Kinetics of Hydrolysis of Flutazolam and Haloxazolam in Aqueous Solution
- The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media. II. Kinetics and Mechanism of the Acid-Base Equilibrium Reaction of Oxazolam
- ヒト血清アルブミンの酵素的活性と薬物結合
- Methanesulfonic Acid Derivative of Sulfonamide. II. Successively Reversible Hydrolysis of Sulfisoxazole Derivative
- Methanesulfonic Acid Derivative of Sulfonamides. I. Hydrolysis Rate in Vitro and Pharmacokinetics in Vivo
- Effects of Drug Binding on the Esterase-Like Activity of Human Serum Albumin. IV. Application of an Analog Computer to Determination of the Multiple Dissociation Constants
- Release Rates of Substituted Aniline from Its Methanesulfonic Acid Derivative in Acid Region
- Effect of ortho-Substituents on Methanesulfonic Acid Derivative of Substituted Aniline
- Methanesulfonic Acid Derivative of p, p'-Diaminodiphenylsulfone. II. Pharmacokinetics and Availability of Parental Drug in Rabbit
- Methanesulfonic Acid Derivative of p, p'-Diaminodiphenylsulfone. I. Hydrolysis Rate in Vitro