Methanesulfonic Acid Derivative of Sulfonamide. II. Successively Reversible Hydrolysis of Sulfisoxazole Derivative
スポンサーリンク
概要
- 論文の詳細を見る
Successively reversible hydrolysis of methanesulfonic acid derivative of sulfisoxazole, R'NHSO_2C_6H_4NHCHRSO_3Na (R=CH_3 or C_6H_5), was studied. By the sequential hydrolysis such derivative may be hydrolyzed to the extent that the precipitation of parental drug may take place. The pH-profiles of logarithm of apparent hydrolysis and reverse reaction rates and those of equilibrium constants were obtained and the effect of ionizations of the derivatives and hydrolyzates have been explained by theoretical equations. From the hydrolysis and reverse reaction rates estimated, reaction pathway of individual reactions which compose whole hydrolysis system has been discussed.
- 公益社団法人日本薬学会の論文
- 1972-08-25
著者
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黒野 幸久
神戸大学 大学院医学系研究科精神神経科学分野
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池田 憲
Faculty Of Pharmaceutical Sciences Nagoya City University
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黒野 幸久
Faculty of Pharmaceutical Sciences, Nagoya City University
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塚本 長太郎
Faculty Of Pharmaceutical Sciences Nagoya City University
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