Kinetics and Mechanism of the Acid-Base Equilibrium and the Subsequent Hydrolysis of 11b-Hydrogenbenzodiazepinooxazoles

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概要

• 論文の詳細を見る

• Oxazolidine ring-opening and ring-closing reactions of 11b-hydrogen(11b-nonsubstituted)benzodiazepinooxazoles (HBDOZ) and the subsequent hydrolysis of the diazepine ring were studied kinetically. The difference in the reactivities of the oxazolidine ring between cis and trans isomers (referring to substitutents at the 2- and 11b-positions) for HBDOZs is small, compared with those for BDOZs having 11b-methyl (MBDOZ) and 11b-phenyl groups (PBDOZ) reported previously. The reactions of the oxazolidine ring for HBDOZ occur about 10 times faster than those for MBDOZ and PBDOZ. For HBDOZ, hydrolysis of the amide bodn of the diazepine ring takes place rather than that of the iminium bond, in contrast to the cases of MBDOZs and PBDOZs.

• 公益社団法人日本薬学会の論文
• 1990-01-25

著者

• 黒野 幸久

  神戸大学 大学院医学系研究科精神神経科学分野

• 池田 憲

  名古屋市立大学薬学部

• 池田 憲

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 八代 有

  Faculty of Pharmaceutical Sciences Nagoya City University

• 八代 有

  名古屋市立大学薬学部

• 黒野 幸久

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 桑山 知成

  Pharmacy, NTT Tokai General Hospital

• 沢辺 博司

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 八代 有

  名古屋市立大学

• 桑山 知成

  Pharmacy Ntt Tokai General Hospital

• 沢辺 博司

  Faculty Of Pharmaceutical Sciences Nagoya City University

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