Antineoplastic Activity of Platinum Complexes of trans-(dl)-1,2-Cyclopentanediamine
スポンサーリンク
概要
- 論文の詳細を見る
Dichloro-trans-(dl)-1,2-cyclopentanediamineplatinum (II) and its derivatives, mixed ligand complexes with oxalato, malonato, or sulfato, were synthesized and tested against Leukemia P-388. All of these complexes have high antineoplastic activity. Among them sulfato-trans-(dl)-1,2-cyclopentanediamine revealed a very high therapeutic index and is more effective than the corresponding complex of 1,2-cyclohexanediamine.
- 社団法人日本薬学会の論文
- 1979-03-25
著者
-
塚越 茂
癌研究会癌化学療法センター
-
喜谷 喜徳
Faculty of Pharmaceutical Sciences Nagoya City University
-
稲垣 健治
Faculty of Pharmaceutical Sciences Nagoya City University
-
八代 有
Faculty of Pharmaceutical Sciences Nagoya City University
-
田代 田鶴子
Division of Experimental Chemotherapy Cancer Chemotherapy Center
-
塚越 茂
Division of Experimental Chemotherapy Cancer Chemotherapy Center
-
塚越 茂
帝国臓器製薬
-
八代 有
General Instrument And Analytical Center Faculty Of Pharmaceutical Sciences Nagoya City University
関連論文
- 新モルヒネ経皮吸収型製剤とその臨床応用への可能性
- オクテット
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. III. Novel N-Glycosylamino-indolo[3,2-b]quinolines
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives
- 癌化学療法 : 基礎から臨床へ
- 公開講座:シンボジウム-特殊病態下での抗菌薬・抗癌薬化学療法の問題点
- 癌化学療法-その問題点と将来
- 在宅治療を考慮した抗癌剤の開発 (癌の在宅治療)
- 抗癌剤の作用点と分類
- 新しい抗癌剤の開発動向
- バイオテクノロジ-素材としての培養細胞-13-癌化学療法
- THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF TROPOLONE AND 8-HYDROXYQUINOLINE DERIVATIVES
- がん治療の本
- 癌治療の現場から(がん治療薬研究の現場から)
- Biological response modifier〔和文〕
- がん制圧の夢を語る
- 抗癌剤の研究
- Antineoplastic Activity of Platinum Complexes of trans-(dl)-1,2-Cyclopentanediamine
- Kinetics and Mechanism of Tautomerism of a Hydroxy Schiff Base, N-[2-{2-Hydroxyethylimino(methyl)methyl}phenyl]-2-chlorpropamide, in Solution
- Regiospecific Nitration of Quinoline and isoquinoline through the Reissert Compounds
- Kinetics and Mechanism of the Acid-Base Equilibrium and the Hydrolysis of Benzodiazepinooxaziines
- Reissert-Type Reaction of N-Sulfonyl- or N-Acyl-phthalazinimum Salts with Trimethyl Phosphite and Crystal Structure of Dimethyl 2-Mesyl-1,2-dihydro-1-phthalazinylphosphonate
- The Crystal and Molecular Structure of Racemic 11b-Methylbenzodiazepinooxazole
- 1R,2R-シクロヘキサンジアミンを配位子にもつ四価および二価白金錯体の細胞毒性(発表論文抄録(1993))
- Cytotoxicity of Platinum(IV) and Platinum(II) Complexes Containing 1R, 2R-Cyclohexanediamine as a Ligand
- Syntheses and Antitumor Activities of 1R,2R-Cyclohexanediamine Pt(II) Complexes Containing Dicarboxylates(Medicinal Chemistry,Chemical)
- Examination of antitumor activities of platinum complexes of 1,2-diaminocyclohexane isomers and their related complexes(Communication)
- 原子吸光分析法によるアミノ酸の間接定量に関する研究(その2)
- Synthesis of Spiro [4-hydroxycyclohexane-1,4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline] and 4-Dimethylaminomethyl-4-(m-methoxyphenyl) cyclohexanol
- Synthesis of Spiro [4-hydroxycyclohexane-1,4'-2', 3'-dihydro-6'-methoxy-1'-substituted-2'-methyl-1'H-isoquinoline]
- 溶媒抽出,原子吸光光度法によるヒスタミンの選択的定量
- Colorimetric Determination of Urinary Xanthurenic Acid Using an Oxidative Coupling Reaction with N, N-Diethyl-p-phenylenediamine
- Use of the o-Phenylenediamine Fluorescence System in the Enzymatic Assay of Serum Uric Acid
- Determination of Acetaldehyde in Human Blood by High-Performance Liquid Chromatography Using Fluorometry
- Zinc Deficient Bovine Erythrocyte Superoxide Dismutase Has Low Specific Activity
- Kinetics and Mechanism of the Acid-Base Equilibrium and the Subsequent Hydrolysis of 11b-Hydrogenbenzodiazepinooxazoles
- cis/trans Isomerization Rate of Oxazolam in Organic Solvents Measured by High-Performance Liquid Chromatography
- The Crystal Structure and Absolute Configuration of the Antitumor Platinum Complex tran(OH)-Pt(OH)_2(Malonato)(1R, 2R, -Cyclohexanediamine)
- Studies on Synthesis, Structure, and Antitumor Activity of Pt(II) Complexes Containing 1,2-Diamino-1,2-dideoxy-D-glucitol
- The Measurement of cis-Platin and trans-Platin by Graphite Atomic Absorption Spectrophotometry
- Synthesis and Antitumor Activity of Novel Dolastatin 10 Analogs
- Studies of Copper-Binding Behavior of Copper-Free and Apo-superoxide Dismutase by High-Performance Liquid Chromatography
- Magnetic Circular Dichroic Spectra of Various Adducts of Co (II)-Bovine Carbonic Anhydrase
- Coordination Chemical Studies on Metalloenzymes. VIII. Reduction of Co (III)-Bovine Carbonic Anhydrase with L-Ascorbic Acid
- Coordination Chemical Studies on Metalloenzymes. IV. Kinetic and Thermodynamic Studies of Metal Removal Reaction from Zinc-and Cobalt-Carbonic Anhydrase with Chelating Agents
- オクテット
- 過剰な亜鉛イオンによるカルボキシペプチダ-ゼAの活性阻害作用--タンパク質の立体構造変化の可能性 (生体関連物質と配位化学) -- (金属酵素・金属タンパク質)
- 各種キレ-ト化剤による炭酸脱水酵素からの金属除去反応に対するpHと活性阻害剤の影響
- 高速液体クロマトグラフィ-によるCr(3)の定量
- Absorptiometric Measurement of Hydrogen Peroxide in Submicromolar Amounts
- Liquid Chromatographic Assay of Plasma Hemoglobin Based on Oxidative Quenching of Serotonin by Pseudoperoxidase Effect of Hemoglobin
- Kinetics and Mechanism of Reversible Hydrolysis of 11b-Methylbenzodiazepinooxazoles
- Kinetics and Mechanism of the Acid-Base Equilibrium of Benzodiazeinooxazoles : Oxazolam Analogs
- The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media. IV. Proton and Carbon-13 Nuclear Magnetic Resonance Spectra of Diazepam and Fludiazepam in Acidic Aqueous Solution
- The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media. III. Carbon-13 Nuclear Magnetic Resonance Spectra of Flutazolam in Acidic Aqueous Solution
- Studies on Mass Spectrometry of Metal Chelates. II. Mass Spectrometric Investigation of Thiooxine Metal Chelates
- 原子吸光分析法による葉酸の間接定量法
- 原子吸光分析法によるベンジルペニシリンの間接定量法
- 白金錯体の制がん効果--最近の話題
- 制癌作用を有する白金錯体の化学 (金属と薬理活性)
- 医薬品としての金属錯体"プラチナががんをなおす" (有機金属錯体--広がるその領域)
- 金属含有医薬品開発の現況 (微量元素と生物圏)
- 内科100年の変遷 癌研究100年の変遷
- DDS研究と癌治療薬研究の将来展望
- 癌治療とDDS
- 癌化学療法のoverview - DDS研究の立場から -
- Synthesis and Antitumor Activity of Pt (II) Complexes containing 2,3-Diaminopropanol Isomers
- Colorimetric Assay of Diamine Oxidase Activity with Histamine as the Substrate(Analytical,Chemical)
- Synthesis of Pt(II) Complexes Containing D-Glucuronate, D-Gluconate, or Their Acetyl Derivatives and Evaluation of Antitumor Activity against Murine Leukemia L1210
- Synthesis and Antitumor Activity of Riboflavin and Flavin Mononucleotide Pt(II) Complexes
- Antitumor Activity of Pt(II) Complexes Containing Diaminocarboxylates and Their Ester Derivatives
- Platinum Complexes of Diaminocarboxylates and Their Ethyl Ester Derivatives : Antitumor Activity and Interaction with Deoxyribonucleic Acid
- Cytotoxicity of Asymmetric Platinum Complexes against L-1210 Cells. Effect of Bulky Substituents
- オランダからの留学生(薬系大学における国際交流 : 海外からの留学生受け入れ)
- 高速液体クロマトグラフィ-による抗がん活性白金錯体とDNAおよび核酸塩基との相互作用に関する研究 (最新の化学分離法) -- (クロマトグラフィ-)
- STERIC EFFECT IN BINDING OF ANTITUMOR ACTIVE PLATINUM (II) COMPLEX TO NUCLEIC ACID BASE
- 制癌性白金錯体の研究
- Direct Determination of cis-Dichlorodiammineplatinum (II) in Urine by Derivative Spectroscopy
- 第9回毒物コントロールセンター欧洲連合国際会議, 国際裁判化学毒物者欧洲会議および第8回国際微量化学シンポジウム
- Studies on the Metal Chelate Compounds of Phenazine Derivatives. XI. Metal Chelates of 1-Phenazinethiol
- 原子吸光分析法によるパラアミノ安息香酸の間接定量
- 2,3-ジメチル-5-ヒドロキシキノキサリン及び1-ヒドロキシ-6,7,8,9-テトラヒドロフェナジンの金属キレートの安定度定数
- 原子吸光分析法によるアントラニル酸の間接定量
- Studies on the Metal Chelate Compounds of Phenazine Derivatives. IX. : Formation Constants of Metal Chelates of Hydroxybenzo [a]-phenazine Derivatives
- Phenazine誘導体の金属キレートの研究(第8報)1-Hydroxyphenazineの金属錯体
- Studies on the Mixed-Ligand Complexes. III. Mixed-Ligand Complexes between Alloxan and Glycine with Bivalent Metals
- Studies on the Mixed-Ligand Complexes. II. Synthesis of the Mixed-Ligand Complexes between 8-Hydroxyquinoline-5-sulfonic Acid and L-Histidine with Metals
- Studies on the Mixed Ligand Complexes. I. Synthesis of Glycine Oxine Cobalt (III) Complex
- 新規抗癌剤TZT-1027の抗腫瘍活性
- Synthesis of 1-(Methylthio) phenazine Platinum (II) and Its S-demethylated Complexes
- 金属錯体化学からみた発癌と制癌
- 8-アミノキノリンのCu(II), Pt(II), Pd(II)錯体の合成
- 原子吸光分析法によるアミノ酸の間接定量に関する研究 : その1
- Studies on the Metal Chelate Compounds of Phenazine Derivatives. XII. Far-infrared Spectra of the Metal Chelates of Hydroxyphenazine Derivatives
- 制がん作用をもった白金錯体 (金属イオンの生物活性--生物無機化学の新しい流れ)
- Preparation of Platinum (II) Complexes of Diamine Isomers [PtX (1,3-Diamine)] (X=Cl_2,SO_4,(NO_3)_2,Oxalato, D-Glucuronato, and D-Gluconato) and Determination of Their Antitumor Activity against Leukemia L1210
- Antitumor Activity of Platinum(2) Complexes of 1,2-Diamino-Cyclohexane Isomers
- Synthesis of Platinum (II) Complexes of 4-Substituted o-Phenylenediamine Derivatives and Determination of Their Antitumor Activity
- 白金錯体の合成と抗腫瘍活性
- 制がん作用を有する白金錯体