Antitumor Activity of Pt(II) Complexes Containing Diaminocarboxylates and Their Ester Derivatives

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概要

• 論文の詳細を見る

• Antitumor Pt(II) complexes containing ester derivatives of DL-2,3-diaminopropionate and DL-2,4-diaminobutyrate were synthesized and their structures were determined from their infrared and ultraviolet absorption spectral data. The antitumor activity of these Pt(II) complexes was tested in vivo against leukemia L1210 according to the NCI Pt Analog Protocol. [Pt(Malonato)(DL-2,3-diaminopropionate ethyl ester)] exhibited the highest antitumor effect with a T/C% value of 364 at an administration dose of 100 mg.The partition coefficients between water and n-octanol were measured, but no clear correlation with antitumor effects was found.

• 公益社団法人日本薬学会の論文
• 1986-06-25

著者

• 喜谷 喜徳

  Faculty of Pharmaceutical Sciences Nagoya City University

• 田代 田鶴子

  Division of Experimental Chemotherapy Cancer Chemotherapy Center

• 野路 雅英

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 鈴木 憲治郎

  Department of Pharmacy, Tokai Teishin Hospital

• 喜谷 喜徳

  名古屋市立大学薬学部

• 野路 雅英

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 鈴木 憲治郎

  Department Of Pharmacy Tokai Teishin Hospital

• 野路 雅英

  名古屋市大 薬

• 花村 真吾

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 花村 真吾

  Faculty Of Pharmaceutical Sciences Nagoya City University

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