Synthesis and Antitumor Activity of Fused Quinoline Derivatives

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概要

• 論文の詳細を見る

• Some tetracyclic quinolines (9 and 14) with a [2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino side chain were prepared and their deoxyribonucleic acid (DNA) intercalative properties, KB cytotoxicity, antitumor activity (P388 leukemia), and ability to induce topoisomerase II dependent DNA cleavage were investigated. The indoloquinoline derivative 9 exhibited the most potent activity (dose=6.3mg, T/C%=300) in this series. The steric structural features of the chromophores of the compounds previously and newly synthesized were studied by a computer-associated molecular graphics technique. Relationships between the steric structural features of the chromophores and biological activities are also discussed.

• 社団法人日本薬学会の論文
• 1990-11-25

著者

• 竹内 靖雄

  岡山大学薬学部

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 張 明栄

  Faculty of Pharmaceutical Science, Okayama University

• 竹内 靖夫

  Faculty of Pharmaceutical Sciences, Okayama University

• 鶴尾 隆

  Faculty of Pharmaceutical Sciences, Okayama University

• 田代 田鶴子

  Faculty of Pharmaceutical Sciences, Okayama University

• 塚越 茂

  Faculty of Pharmaceutical Sciences, Okayama University

• 塚越 茂

  癌研究会癌化学療法センター

• 塚越 茂

  癌研究会癌研究所

• 田代 田鶴子

  Division of Experimental Chemotherapy Cancer Chemotherapy Center

• 鶴尾 隆

  財団法人癌研究会 癌化学療法センター

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Science Okayama University Of Science

• 竹内 靖夫

  Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center

• 塚越 茂

  帝国臓器製薬

• 塚越 茂

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 張 明栄

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

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