The Synthesis on N-Methyl[^<14>C]-bis(2-chloroethyl)amine N-Oxide and its Excretion in the Urine of Dog.
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概要
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N-Methyl[^<14>C]-bis(2-chloroethyl)amine N-oxide (^<14>C-labeled nitrogen mustard N-oxide) was synthesized for pharmacological and biochemical experiments using Methyl-[^<14>C]iodide. Its specific activity was determined as 6,500 counts/min./μmole by Q-gas flow counter. The labeled compound was given to a dog intravenously and the urine was taken out from the opened bladder. Concentration of the compound in the urine was quantitatively determined by radioactivity measurement.
- 公益社団法人日本薬学会の論文
- 1960-02-25
著者
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塚越 茂
Faculty of Pharmaceutical Sciences, Okayama University
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塚越 茂
Faculty Of Pharmaceutical Sciences University Of Tokyo
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石館 守三
Tokyo Biochemical Research Institute
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石館 守三
Faculty of Pharmaceutical Sciences, University of Tokyo
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石館 守三
Faculty Of Pharmaceutical Sciences University Of Tokyo
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