Studies on Carcinostatic Substances. XXVI. Preparation of Bis(2-chloroethyl)amine Derivatives and Related N-Oxides.

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概要

• 論文の詳細を見る

• Twenty new derivative of nitrogen mustard, including six N-oxides, were prepared and tested for their in vivo and in vitro antitumor activity against the Yoshida.

• 公益社団法人日本薬学会の論文
• 1960-02-25

著者

• 桜井 欽夫

  Cancer Institute Japanese Foundation For Cancer Research

• 愛甲 軍雄

  Yoshitomi Pharmaceutical Industries Ltd.

• 石館 守三

  Tokyo Biochemical Research Institute

• 桜井 欽夫

  Iatrochemical Institute Of The Pharmacological Research Foundation Tokyo

• 石館 守三

  Iatrochemical Institute of Pharmacological Research Foundation

関連論文

• Synthesis of Amino Sugar Containing Disaccharides. The Synthesis of Hyalobiuronic Acid and Chondrosine
• Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. V. Quantitative Analysis of Biliary and Urinary Metabolites of 4-Dimethylaminoazobenzene in Rat.
• On the Optical Isomers of α-[N-Bis (β-chloroethyl) amino] propionamide.
• Polarographic Determination of Half-wave Potentials of Nitrogen Mustard N-Oxides
• Bacteriostatic Activity of the Nitrogen Mustard N-Oxides against Escherichia coli
• N-Oxides of β-Chloroethylamine Derivatives.
• Studies on Carcinostatic Substances. XLI. Preparation of Azide Derivatives of 1,1-Bis (2-chloroethyl) hydrazine.
• The Effect of Anti-tumor Agents on the Dehydrogenase Activity of Tumors.
• Studies on the Glucaric Acid Pathway in the Metabolism of D-Glucuronic Acid in Mammals. III. Determination of D-Glucaric Acid in Serum, with Special Reference to Its Level after Administration of D-Glucuronolactone and D-Glucarolactones to Man
• Studies on the Glucaric Acid Pathway in the Metabolism of D-Glucuronic Acid in Mammals. II. Excretion of D-Glucaric Acid in Urine after Administration of Several Monosaccharides and Their Derivatives to Mammals
• Conversion of D-Mannuronolactone into D-Mannaric Acid in Mammalian Systems
• Studies on Carcinostatic Substances. XXXII. : Acquired Resistance of Yoshida Sarcoma by Treatment with Derivatives of Nitrogen Mustard.
• Studies on Carcinostatic Substances. XXVII. Anti-tumor Activity of 2-Chloroethylamine Derivatives on the in vitro-Cultured Yoshida Sarcoma Cells
• Studies on Carcinostatic Substances. XXII. Screening Method for Antimitotic Substance using the in vitro-Cultured Yoshida Sarcoma Cells.
• Studies on Carcinostatic Substances. XX. Studies on the Culture of Yoshida Sarcoma Cells in vitro.
• Synthesis and Evaluation of the Anticancer Activity of a New Series of Methanesulfonates
• Synthesis and Evaluation of the Anticancer Activity of Some Water Soluble Maleimide Derivatives
• Fatty Acid Components of Lipid Fractions of Yoshida Sarcoma and Rat Ascites Hepatomas
• Carcinostatic Activity of Several New Derivatives of Sulfonic Acid esters of Some Aminoglycols
• Preparation of Derivatives of Nitrogen Mustard having Structure of α-Amino Acid Amide
• Carcinostatic Methanesulfonic Acid Esters of Some Aminoglycols
• Carcinostatic Methanesulfonic Acid Esters of Nitrogen Mustard Analogs
• Studies on Carcinostatic Substances. XXXVII. Preparation of Derivatives of Nitrogen Mustard having Metal Chelate-forming Activity.
• Studies on Carcinostatic Substances. XXXVI. A New Type of Antitumor Derivatives of Nitrogen Mustard with Latent Activity.
• Studies on Carcinostatic Substances. XXXIV. Anti-tumor Activity of 2,2-Bis (2-chloroethyl) isoxazolidinium Chloride and Related Compounds.
• Studies on Carcinostatic Substances. XXX. Syntheses of Derivatives of Nitrogen Mustard related to Amino Acid.
• Paper Chromatographic Detection of Nitrogen Mustard
• Studies on Carcinostatic Substances. XXIX. 1,1-Bis(2-chloroethyl)-hydrazine and its Derivatives as Tumor-inhibiting Agent
• Studies on Carcinostatic Substances. XXVI. Preparation of Bis(2-chloroethyl)amine Derivatives and Related N-Oxides.
• Studies on Carcinostatic Substances. XXIV. Preparation of Diphenylphosphoric Acid Esters of N-Methyl-and N-Phenyl-bis(2-hydroxyethyl)amine and their Alkylating Activity.
• Studies on Carcinostatic Substances. XXIII. Correlation between Anti-tumor and leucopenia-inducing Effects of Alkylating Agents
• The Synthesis on N-Methyl[^C]-bis(2-chloroethyl)amine N-Oxide and its Excretion in the Urine of Dog.
• Reaction of Amide Homologs. III. α-Acylamidoalkylation of 2,4-Xylenol with Bisamides.
• Rearrangement Reaction of 7-Mercaptooxazolo[5,4-d]pyrimidine to 7-Hydroxythiazolo[5,4-d]pyrimidine
• Syntheses of Thiazolo-[5,4-d]pyrimidine Derivatives and Related Compounds.
• Studies on Carcinostatic Substances. XXXIII. Preparation of Derivatives of Nitrogen Mustard of Strongly Basic Character.
• 3-Ketoglucuronic Acid. II. Constitution and Chemical Properties of 3-Ketoglucuronic Acid
• 3-Ketoglucuronic Acid. I. Synthesis of 3-Ketoglucuronic Acid
• Synthesis of 3-Keto-D-glucuronic Acid
• A New Reductone derived from D-Glucuronolatone, 3-Keto-4,5-dideoxy-trans-4,5-dehydroglucuronic Acid
• A New Action of Anion Exchange Resins on the Lactone Ring of Some Carbohydrates
• Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. III. Metabolites of 4-Dimethylaminoazobenzene in Rat Bile and Influence of DAB Feeding on their Amounts
• Studies on L-Gulonic Acid Derivatives. III. Synthesis of Benzyl 2,4,5,6-Tetra-O-benzyl-L-gulonate and Its Oxidation
• Studies on L-Gulonic Acid Derivatives. II. Benzoyl Migration in Derivatives of D-Glucitol
• 1,1-Bis (2-chloroethyl) hydrazine and its Antitumor Activity
• Studies on Carcinostatic Substances. XIX. The Preparation and Properties of N, N'-Bis (2-chloroethyl)-N, N'-dimethylpolymethylenediamine N, N'-Dioxides.
• Studies on Carcinostatic Substances. XVIII. Anticancer Action of N, N'-Bis (2-chloroethyl)-N, N'-dimethylpolymethylenediamines.
• Studies on Cancerocidal Substances. XVII. Reaction of Nitrogen Mustard N-Oxides and Amino Acid.
• Studies on Cancerocidal Substances. XVI. Some Sulfonic Acid Esters as Anti-cancer Agents.
• Studies on Cancerocidal Substances. XV. Preparation of Some New Azo Derivatives of Bis (β-chloroethyl) amine.

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