3-Ketoglucuronic Acid. I. Synthesis of 3-Ketoglucuronic Acid
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概要
- 論文の詳細を見る
3-Ketoglucuronic acid, a new 1,3-dicarbonyl carbohydrate, was synthesized. 5-O-Acetyl-1,2-O-isopropylidene-D-glucofuranurono-6,3-lactone (I) was converted into methyl 5-O-acety-1,2-O-isopropylidene-D-glucofuranuronate (IId), which was oxidized with chromium trioxide to give 3-keto-5-O-acetyl-1,2-O-isopropylidene-D-glucofuranuronate (III). Ethyl acetate was found to be an excellent solvent for this oxidation. Removal of protective groups from III afforded crystalline 3-ketoglucuronic acid (VII). The intermediate substance (III) underwent stereo-selective reduction by the action of lithium aluminum hydride to produce 1,2-O-isopropylidene-D-allofuranose.
- 公益社団法人日本薬学会の論文
- 1966-09-25
著者
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田村 善蔵
Faculty of Pharmaceutical Sciences, University of Tokyo
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木下 俊夫
School of Pharmaceutical Sciences, Kitasato University
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石館 守三
Tokyo Biochemical Research Institute
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田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
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田村 善蔵
Pharmaceutical Institute School Of Medicine Keio University
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木下 俊夫
School Of Pharmaceutical Sciences Kitasato University
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木下 俊夫
Faculty of Pharmaceutical Sciences, University of Tokyo
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