A New Fluorometric Analysis of Dulcin using Sodium Nitrite. IV. Studies on the Reaction Mechanism
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概要
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The reaction mechanism of the fluorometric determination of dulcin with sodium nitrite was studied and estimated as follows : Dulcin produces 4-ethoxybenzenediazonium (4EBD) ion via. p-phenetidine by the action of nitrous acid. The ion itself decomposes in part to the substances possessing the active methylene neighbouring to a carbony group. Finally, 4EBD ion reacts with the active methylene in the presence of an alkaline solution containing nitrous oxide to form the essential fluorescent compound, 1,3-bis (4-ethoxyphenyl)-5-tetrazolone.
- 公益社団法人日本薬学会の論文
- 1975-05-25
著者
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田村 善蔵
Faculty of Pharmaceutical Sciences, University of Tokyo
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内山 貞夫
National Institute of Hygienic Sciences
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田村 善蔵
東京大学医学部
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田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
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内山 貞夫
国立衛生試験所
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