Hydrolysis of 5-Chloro-7-iodo-8-quinolinol Conjugates catalyzed by Metal Ions
スポンサーリンク
概要
- 論文の詳細を見る
Glucuronide (CF-G) and sulfate (CF-S) of 5-chloro-7-iodo-8-quinolinol were hydrolyzed in water in the presence of metal ions at pH 7. In this condition, CF-G was hydrolyzed more easily than CF-S. The rate of the hydrolysis, pseudo-first order reaction, was in parallel with the stability constants of 8-quinolinol-metal complexes. The rate of hydrolysis increased with reduction of concentration of H^+ and tris buffer suppressed the hydrolysis of CF-G. These results suggest that metal catalyzed hydrolysis of CF-G and CF-S was derived from the formation of complexes between the conjugates and metal ions.
- 公益社団法人日本薬学会の論文
- 1976-06-25
著者
-
田村 善蔵
Faculty of Pharmaceutical Sciences, University of Tokyo
-
今成 登志男
Faculty Of Pharmaceutical Sciences Chiba University
-
陳 鏡潭
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
早川 和一
Faculty of Pharmaceutical Sciences, Kanazawa University
-
田村 善蔵
東京大学医学部
-
田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
関連論文
- 2-CARBOXY-1-HYDROXY-4-NAPHTHYLMETHYLDIMETHYLSULFONIUM CHLORIDE AS A NEW FLUORESCENT KOSHLAND REAGENT
- Fluorometric Determination of Biogenic Indole Compounds using Perchloric Acid
- Determination of Fluorescein and Fluorescein Monoglucuronide excreted in Urine
- Studies on the Metabolites of Fluorescein in Rabbit and Human Urine
- Simultaneous Determination of Multiple Enzyme Activities by High Performance Liquid Chromatography
- Supplemental Studies on Relationship between Structure and Spectrum of Fluorescein
- Spectrophotometric Determination of Bunte Salts as Bisulfite with Acidbleached Basic Fuchsine or N-(p-Dimethylaminophenyl)-1,4-naphthoquinoneimine after Reduction with Dithiothreitol
- Fluorescence Reaction of Bisulfite with Indophenol Blue and Its Application to Determination of Bisulfite
- A Simple Synthesis of Amino-containing Bunte Salts by the Reaction of Aminothiols with Chlorosulfonic Acid
- Spectrophotometric Determination of Bunte Salts
- Fluorometric Assay of Bisulfite
- The Production of Bisulfite from Pantetheine-S-sulfonic Acid by Bifidobacterium bifidum
- Studies on the Metabolites in Urine and Feces of Rat after Oral Administration of Radioactive Pantethine
- Gas Chromatographic Analysis of Disaccharides. II. Analysis of Disaccharides in Human Body Fluids
- Mechanism of Utilization of Pantetheine-S-Sulfonic Acid by Bifidobacterium bifidum
- Gas Chromatography of Catecholamines and Related Compounds
- Relationship between Neurological Symptoms and Concentrations of Clioquinol in Serum and Nervous Systems of Beagle Dogs
- Gas Chromatography and Its Combination with Mass Spectrometry of Urinary Sugar Alcohols
- Fluorometric Analysis of Pyruvic Acid with 4'-Hydrazino-2-stilbazole
- A New Ultra-micro Microbioassay
- Behaviour of Plasma Sugars after Oral Administration of Lactose
- Gas Chromatographic Analysis of Disaccharides. I. Analysis of Disaccharides as Trimethylsilyl and Trifluoroacethyl Derivatives of Corresponding Alditols
- Fluorometric Determination of Pyridoxal-5-phosphate and Pyridoxal in Biological Materials. II. Specificity of the Method in Pyridoxal-5-phosphate Determination.
- Fluorometric Determination of Pyridoxal-5-phosphate and Pyridoxal in Biological Materials. I. Procedure and Application.
- Fluorometric Determination of Catecholamines on a Three-Phase Thin-Layer Plate
- Fluorometric Determination of Cyanide by the Reaction with Pyridoxal
- Reaction of Pyridoxal with Cyanide
- High-Performance Liquid Chromatographic Determination of L-3,4-Dihydroxyphenylalanine (L-DOPA) and Its Metabolites in the Urine of Patients with Parkinson's Disease, Control Patients and Normal Subjects after Oral Administration of L-DOPA
- Presence of (±)-δ-(3,4-Dihydroxyphenyl)-γ-valerolactone in Human Urine
- Gas Chromatography of Copper (II) and Nickel (II) Chelates of Some β-Ketoimine Derivatives of 2,4-Pentanedione and Salicylaldehyde
- Metal Complexes of D-Glucosamine and its Derivatives. VII. Metal Complexes of D-Glucosaminic Acid
- Metal Complexes of D-Glucosamine and its Derivatives. VI. Determinations of Stability Constants of Copper Complexes of Methyl-β-D-glucosaminide and of 3,4,6-Tri-O-methyl-D-glucosamine by pH Titration Method
- Metal Complexes of D-Glucosamine and its Derivatives. V. Spectrophotometric Investigations on Copper (II), Nickel (II), and Cobalt (II) Complexes of D-Glucosamine and the Preparation of Glucosamine-copper Complex
- Metal Complexes of D-Glucosamine and its Derivatives. IV. Determinations of Stability and Equilibrium Constants of Metal Complexes of D-Glucosamine by pH Titration Method
- Metal Complexes of D-Glucosamine and its Derivatives. III. Determinations of Acid Dissociation Constants of D-Glucosamine and its Three O-Methyl Derivatives
- 1.有害性金属のペーパークロマトグラフ法による定量法(第10回日本薬学大会衛生化学・分析化学シンポジウム(其の2)有害性金属の微量定量法)
- Semiquinone Radicals Generated from Catecholamines by Ultraviolet Irradiation
- 3-O-β-D-Glucopyranosiduronyl-D-glucaro-1,4-lactone
- Gas Chromatography of D-Glucaric Acid and Its Lactones, and Application to Measuring Their Transformation
- Synthesis of 5-Chloro-7-iodo-8-quinolinol (Chinoform) Glucuronide
- Studies on the Components of Clerodendron trichotomum THUNB. III. A New Glycoside, Acacetin-7-glucurono-(1→2)-glucuronide from the Leaves
- Selective Methanolysis of Lactone Rings in Some Acyl Carbohydrates
- Determination of Neutral and Amino Sugars in Glycoproteins by Gas Chromatography
- Serum Levels of 5-Chloro-7-iodo-8-quinolinol and Its Toxicity in Various Animals
- Hydrolysis of 5-Chloro-7-iodo-8-quinolinol Conjugates catalyzed by Metal Ions
- A Gas Chromatographic Determination Method of 5-Chloro-7-iodo-8-quinolinol and Its Conjugates in Biological Fluids
- Analysis of 5-Chloro-7-iodo-8-quinolinol Conjugates by High Performance Liquid Chromatography
- Assay of Arginine-esterase Activities by High Performance Liquid Chromatography
- A New Fluorometric Analysis of Dulcin using Sodium Nitrite. IV. Studies on the Reaction Mechanism
- Synthesis of 5-Chloro-7-iodo-8-quinolinol Sulfate
- A New Fluorometric Analysis of Dulcin using Sodium Nitrite. III. Structural Determination of the Fluorescent Compound by the Single Crystal X-Ray Diffraction Method
- A New Fluorometric Analysis of Dulcin using Sodium Nitrite. II. Isolation and Structural Investigation of the Fluorescent Compound
- Bifidus Factors in Carrot. I. Purification and Some Properties
- Simultaneous Determination of Urinary Uronic Acids and Saccharic Acids by Gas Chromatography
- Isolation and Structural Analysis of a Fluorescent Compound produced by the Reaction of Dulcin with Sodium Nitrite
- Selectivity of Utilization of Galactosyl-Oligosaccharides by Bifidobacteria
- Gas Chromatography of Trifluoroacetyl Derivatives of Alditols and Trimethylsilyl Derivatives of Aldonolactones
- Determination of Vanilpyruvic Acid in Urine by High-Speed Liquid Chromatography
- An Improved Method for the Millon Reaction
- Mechanism of the Millon Reaction. II. The Crystal Structure of Pigment 1
- Mechanism of the Millon Reaction. I. Isolation of Coloring Substances
- Improved Synthesis of Sulfoconjugate Isomers of Norepinephrine and Epinephrine, and Separation of All Sulfoconjugates of Catecholamines by Thin-Layer and High-Performance Liquid Chromatography
- Studies on the Metabolism and Excretion of L-3,4-Dihydroxyphenylalanine (L-DOPA) in Human Beings by Gas Chromatography
- The Plasma Levels of Dopa and Catecholamines after Oral Administration of L-Dopa
- Determination of Vanilmandelic Acid and Homovanillic Acid in Urine by Gas Chromatography
- Gas Chromatographic Determination of 3,4-Dihydroxyphenylalanine (DOPA) in Urine
- Fluorescence Assay of α-Oxo Acids with 4'-Hydrazino-2-stibazole
- Oligosaccharides and Polysaccharides specifically Utilizable by Bifidobacteria
- Determination of 3-Methoxytyramine, Normetanephrine and Metanephrine in Human Plasma by Gas Chromatography
- Synthesis of Norepinephrine-O-sulfates
- Catecholamines in Rat Tissues and Serum determined by Gas Chromatographic Method
- The Presence of Conjugated Dopamine in Normal Human Plasma
- Detection of Catecholamines after N-Dansylation on the Surface of Alumina
- Selective and Sensitive Method for Determination of Vanillylmandelic Acid (VMA) in Urine
- Actual Microanalysis by Large Volume Injection to Gas Chromatograph equipped with Electron Capture Detector
- Synthesis of Epinephrine Monosulfates
- Selective Condensation of Plasma Kinins from Biological Fluids with Siliconised Silica Gel
- Formation of Thiohydantoin Derivative of Proline from C-Terminal of Peptides
- Unexpected Conversion of Epinephrine into Tetrahydroisoquinolines in a Solution containing Ascorbic Acid
- Studies on Radioimmunoassay of Metanephrine
- A Simple Determination of Catechol-O-Methyltransferase Activity
- Preparation of Specific Antibodies to Catecholamines and L-3,4-Dihydroxy-phenylalanine. III. Preparation of Antibody to Epinephrine for Radioimmunoassay
- Preparation of Specific Antibodies to Catecholamines and L-3,4-Dihydroxyphenylalanine. II. The Site of Attachment on Catechol Moiety in the Conjugates
- Preparation of Specific Antibodies to Catecholamines and L-3,4-Dihydroxyphenylalanine. I. Preparation of the Conjugates
- Preparation of a Specific Antibody to Each One of Catecholamines and L-DOPA
- Bifidus Factors in Carrot. III. The Structure of The Factor in Fraction V
- Bifidus Factors in Carrot. II. The Structure of the Factor in Fraction IV
- A Simpler Synthesis of D-Pantothenic Acid 4'-Phosphate
- Metal Complexes of Isonicotinoylhydrazine and Related Compounds. III. Consecutive Formation Constants for Various Metal Ions by the pH Titration Method.
- Metal Complexes of Isonicotinoylhydrazine and Related Compounds. II. Acid Dissociation Constants and Ultraviolet Absorption Spectra of Isonicotinoylhydrazine and Related Compounds.
- New Fluorescence Edman Reagent for Microanalysis of Peptides
- The Total Amino Acid Sequence of Substance A produced by Streptomyces carzinostaticus
- The Amino Acid Sequence around Cystine Residue in Substance A produced by Streptomyces Carzinostaticus
- Gas Chromatography of the Catecholamines as Their Trifluoroacetates in Urine and Tumor
- Gas Chromatography of Catecholamines as Their Trifluoroacetates
- Gas Chromatography of Catecholamines using Dimethyl Sulfoxide as an Effective Solvent for Trimethylsilylation.
- Ultra-micro Analysis of Serum Protein in a Few Nanoliter of Samples
- 3-Ketoglucuronic Acid. II. Constitution and Chemical Properties of 3-Ketoglucuronic Acid
- 3-Ketoglucuronic Acid. I. Synthesis of 3-Ketoglucuronic Acid
- Synthesis of 3-Keto-D-glucuronic Acid