Analysis of 5-Chloro-7-iodo-8-quinolinol Conjugates by High Performance Liquid Chromatography
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概要
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An analytical method of 5-chloro-7-iodo-8-quinolinol (Clioquinol or Chinoform) (CF) conjugates was established by high performance liquid chromatography. The chromatographic conditions were as follows : column, SAX (50 cm×2 mm i.d.) ; mobile phase, I (0.02M borate buffer-0.1M KCl, pH9.5), II (0.02M borate buffer-0.5M NaClO_4,pH 9.5) ; gradient, 0→25% (II/I+II) at 3%/min ; column pressure, 500 psi ; flow rate, 1 ml/min ; detector, ultraviolet-detector at 254 mμ. Urine samples of a man administered CF were injected directly to the column, and the major metabolite, CF glucuronide was determined, while very small amounts of CF sulfate was detected.
- 公益社団法人日本薬学会の論文
- 1975-09-25
著者
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田村 善蔵
Faculty of Pharmaceutical Sciences, University of Tokyo
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今成 登志男
Faculty Of Pharmaceutical Sciences Chiba University
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陳 鏡潭
Faculty Of Pharmaceutical Sciences University Of Tokyo
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早川 和一
Faculty of Pharmaceutical Sciences, Kanazawa University
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田村 善蔵
東京大学医学部
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田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
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