Studies on the Metabolites in Urine and Feces of Rat after Oral Administration of Radioactive Pantethine
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概要
- 論文の詳細を見る
This is the first report describing identifications of PaSSO_3H in nature and P-PaSSO_3H in mammals. Rats fed with solid feed containing PaA excreted PaA and P-PaA in urine, and PaA, P-PaA and PaSS in feces. When ^<14>C-PaSS was orally administered to the rats, 15-35% of the radioactivity was excreted in a week. The amount of radioactivity excreted into urine was about double to that excreted into feces. The metabolites identified are : PaA, PaSS, P-PaA and/or PaSSO_3H and P-PaSSO_3H from urine, and PaA, PaSS, PaSSO_3H, P-PaA from feces. The possible formation mechanisms of PaSSO_3H and P-PaSSO_3H in rat were discussed.
- 社団法人日本薬学会の論文
- 1972-09-25
著者
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中村 洋
Faculty Of Pharmaceutical Sciences University Of Tokyo
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田村 善蔵
Faculty of Pharmaceutical Sciences, University of Tokyo
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田村 善蔵
東大 薬
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田村 善蔵
東京大学薬学部薬品分析化学教室:(現)慶応義塾大学病院薬剤部
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田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
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