Metal Complexes of Isonicotinoylhydrazine and Related Compounds. II. Acid Dissociation Constants and Ultraviolet Absorption Spectra of Isonicotinoylhydrazine and Related Compounds.

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概要

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• Acid dissociation constants of isonicotinoylhydrazine (INH) and seven related compounds were determined by means of pH titration (ionic strength 1.0). Values of pKa obtained were as follows : INH : 2.13,3.81,11.03. nicotinoylhydrazine (NH) : 2.26,3.63,11.49. picolinoylhydrazine (PH) : 1.26,3.07,12.25. benzoylhydrazine (BH) : 3.27,12.53. p-nitrobenzoylhydrazine (PNBH) : 2.90,11.28. isonicotinamide (INA) : 3.82. 1-isonicotinoyl-1-methylhydrazine (N-Me-INH) : 1.03,4.17. 1-isonicotinoyl-2-methylhydrazine (N'-Me-INH) : 2.46,4.04,10.96. The ultraviolet spectra of these compounds at various pH were measured, and the results showed a good parallelism with the pKa values. Some informations about their structures in aqueous solutions were obtained from the spectral data.

• 公益社団法人日本薬学会の論文
• 1963-06-25

著者

• 田村 善蔵

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 長野 晃三

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 木下 恒

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 田村 善蔵

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 木下 恒

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 束原 宏和

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 束原 宏和

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 長野 晃三

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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