Studies on the Metabolism and Excretion of L-3,4-Dihydroxyphenylalanine (L-DOPA) in Human Beings by Gas Chromatography

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概要

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• One gram of L-DOPA was administered orally to the patients with Parkinson's disease and normal persons. Plasma DOPA and catecholamines, urinary DOPA, catecholamines and aromatic acids were determined by gas chromatography both before and after acid hydrolysis. DOPA and dopamine conjugate were detected in the plasma soon after the administration, while large personal deviations were observed both in their concentration and time courses. During 24 hr, 0.53%, 4.24%, 32.0%, and 25.9% in average of the administered L-DOPA were excreted in urine as DOPA, dopamine, DOPAC and HVA respectively in a free and conjugated form.

• 公益社団法人日本薬学会の論文
• 1972-04-25

著者

• 田村 善蔵

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 今井 一洋

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 楢林 博太郎

  Department of Neurology, School of Medicine, Juntendo University

• 楢林 博太郎

  Narabayashi Neurological Clinic

• 楢林 博太郎

  楢林神経内科クリニック

• 田村 善蔵

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 綱川 延孝

  Pharmaceutical Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 綱川 延孝

  Pharmaceutical Research Laboratory Research Laboratories Daiichi Seiyaku Co. Ltd.

• 田村 善蔵

  Pharmaceutical Institute School Of Medicine Keio University

• 大屋 和美

  Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• 大屋 和美

  Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.

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