A Gas Chromatographic Determination Method of 5-Chloro-7-iodo-8-quinolinol and Its Conjugates in Biological Fluids
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概要
- 論文の詳細を見る
A gas chromatographic determination method of 5-chloro-7-iodo-8-quinolinol (CF), its glucuronide (CF-G) and sulfate (CF-S) in serum, urine and milk was developed. 5,7-Dichloro-8-quinolinol and/or 5-chloro-7-bromo-8-quinolinol, and their glucuronides and sulfates were added to the sample as the internal standards. Successive extractions with pyridine-benzene (1 : 9) without treatment, after hydrolysis with β-glucuronidase and that with 1 N HCl at 40°, gave the fractions of free quinolinols, derived from the unconjugated, the glucuronides and sulfates, respectively. The free quinolinols were acetylated and determined by gas chromatography. The present method was a demonstration of an effective use of structurally similar internal standards for determination of a glucuronide and sulfate.
- 公益社団法人日本薬学会の論文
- 1976-01-25
著者
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田村 善蔵
Faculty of Pharmaceutical Sciences, University of Tokyo
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田村 善蔵
東大 薬
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鮫島 啓二郎
Faculty of Pharmaceutical Sciences, University of Tokyo Hongo-7-3-1, Bunkyo-ku, Tokyo, Japan, 113
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陳 鏡潭
Faculty Of Pharmaceutical Sciences University Of Tokyo
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鮫島 啓二郎
Tokyo Biochemical Research Institute
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田村 善蔵
東京大学医学部
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田村 善蔵
東京大学薬学部薬品分析化学教室:(現)慶応義塾大学病院薬剤部
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田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
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鮫島 啓二郎
Faculty Of Pharmaceutical Sciences Josai University
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