3-O-β-D-Glucopyranosiduronyl-D-glucaro-1,4-lactone
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概要
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3-O-β-D-Glucopyranosiduronyl-D-glucaro-1,4-lactone (VI), a new masked inhibitor of β-glucuronidase, was synthesized by the fusion of dimethyl 2,4-O-benzylidene-5-O-acetyl-D-glucarate (I) and methyl 1-bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucopyranuronate (II) in the presence of mercuric cyanide, followed by removal of the protecting groups and lactonization. The chemical structure of VI was confirmed to be 3-O-β-D-glucopyranosiduronyl-D-glucaro-1,4-lactone from the chemical and physical data of the products (III, IV, V, and VI) obtained in the course of its synthesis. The inhibitory effect of VI on β-glucuronidase in vitro was also examined.
- 公益社団法人日本薬学会の論文
- 1973-06-25
著者
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田村 善蔵
Faculty of Pharmaceutical Sciences, University of Tokyo
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田村 善蔵
School of Medicine, Keio University
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田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
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田村 善蔵
School Of Medicine Keio University
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松永 功
Faculty of Pharmaceutical Sciences, University of Tokyo
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松永 功
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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