Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. IV. Metabolites of o-Aminoazotoluene in Rat Bile.
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概要
- 論文の詳細を見る
Biliary metabolites of o-aminoazotoluene (OAT), i. e. 4-amino-3,2'-dimethylazobenzene, were investigated in rat and identified as N-glucuronide of OAT, N-glucuronide of OAT-derivative whose 2'-methyl group was oxidized hydroxymethyl, conjugates of 4'-hydroxylated OAT with sulfuric acid or glucuronic acid, similar conjugates of 4'-hydroxylated and N-acetylated OAT, and a double conjugate of 4'-hydroxylated OAT with N-glucuronic acid and O-sulfuric acid. The method for determination of OAT-NG, a main metabolite, in which an internal standard substance was adopted to thin-layer chromatography, was examined and gave good results. Similar methods were also examined for determination of other minor metabolites.
- 公益社団法人日本薬学会の論文
- 1967-07-25
著者
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石館 守三
Faculty of Pharmaceutical Sciences, University of Tokyo
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田村 善蔵
Faculty Of Pharmaceutical Sciences University Of Tokyo
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鮫島 啓二郎
Faculty Of Pharmaceutical Sciences Josai University
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石館 守三
Faculty Of Pharmaceutical Sciences University Of Tokyo
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鮫島 啓二郎
Faculty of Pharmaceutical Sciences, University of Tokyo
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