A New Method for the Preparation of 2-Alkoxybenzoxazoles

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概要

• 論文の詳細を見る

• A one-pot synthesis of 2-alkoxybenzoxazole (I) from benzoxazoline-2-thione (II) was achieved. Treatment of benzoxazoline-2-thione with methyl iodide followed by an alcohol at room temperature in the presence of sodium hydride gave I. The reaction involves the intermediate of 2-(methylthio) benzoxazole (IIIa), followed by substitution of the methylthio group by an alkoxide anion. The general applicability of this method is discussed.

• 社団法人日本薬学会の論文
• 1983-11-25

著者

• 竹内 靖雄

  岡山大学薬学部

• 竹内 靖雄

  Faculty of Pharmaceutical Sciences, Okayama University

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 服部 京子

  Faculty of Pharmaceutical Sciences, Okayama University

• 服部 京子

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 竹内 靖夫

  Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

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