Polycyclic N-Hetero Compounds. VII. Reactions of Benzyl Ketones with Formamide XI

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概要

• 論文の詳細を見る

• On heating phenylacetone (III) with formamide in the presence of phosphoryl chloride (called the modified Vilsmeier reaction) afforded 4-methyl-5-phenylpyrimidine (IV), 5-phenyl-4-(5-pyrimidinyl) pyrimidine (V), and 3-methyl-2,4-diphenylaniline (VI). The modified Vilsmeier reaction of 3-methoxyphenylacetone (VII) gave 6-methoxy-3-methylisoquinoline (VIII), 4-β-formylaminovinyl-5-m-methoxyphenylpyrimidine (IX), 9-methoxybenzo [f] quinazoline (X), and 7-methoxybenzo [f] quinazoline (XI). The same reaction of 2-phenylcyclohexanone (XII) gave 8-phenyl-5,6,7,8-tetrahydroquinazoline (XIII) and 4-formylamino-4,4a, 5,6,7,8-hexahydroquinazoline (XIV).

• 公益社団法人日本薬学会の論文
• 1975-09-25

著者

• 大和 正利

  Faculty of Science, Okayama University of Science

• 小山 鷹二

  Faculty of Pharmaceutical Sciences, Medical School, Okayama University

• 大森 晋爾

  Faculty of Pharmaceutical Sciences, Medical School, Okayama University

• 廣田 喬

  Faculty Of Pharmaceutical Sciences Okayama University

• 松本 祥子

  Faculty Of Pharmaceutical Sciences Medical School Okayama University

• 大森 晋爾

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 篠原 百里江

  Faculty of Pharmaceutical Sciences, Medical School, Okayama University

• 篠原 百里江

  Faculty Of Pharmaceutical Sciences Medical School Okayama University

• 広田 喬

  岡山大学 薬

• 小山 鷹二

  Faculty Of Pharmaceutical Sciences Okayama University

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