Condensation of Diethyl Acetonedicarboxylate. III. Isolation and Acylation of Diethyl Acetonedicarboxylate-Magnesium Complex
スポンサーリンク
概要
- 論文の詳細を見る
Diethyl acetonedicarboxylate (DADC)-magnesium complex, (DADC)_2Mg (5b), was isolated from the reaction of DADC and MgCl_2 with Et_3N, or by the removal of coordination water from (DADC)_2Mg・2H_2O (5a). Compound 5b could be regarded as an intermediate in the selfcondensation of DADC to give 1,2,3,and 4. A mechanism is proposed for the formation of these products from 5b. Acylation of 5a, b was carried out. The reaction of 5b with acyl chloride gave the monoacylated DADC (9) as the main product. The reaction of 5a, b with diketene afforded diethyl homophthalate (4) and orsellinic acid (11) derivatives, formed by acylation and subsequent cyclization.
- 公益社団法人日本薬学会の論文
- 1981-05-23
著者
-
大和 正利
Faculty Of Pharmaceutical Sciences Okayama University
-
楠 洋一郎
Faculty Of Pharmaceutical Sciences Okayama University
関連論文
- Alkoxycarbonylmethylation of(3R, 10bS)-3-Phenyl-2,3,5,6-tetrahydro-10bH-oxazolo[2,3-a]isoquinoline
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. III. Novel N-Glycosylamino-indolo[3,2-b]quinolines
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. II. Novel 4- and 7-Hydroxyindolo-[3,2-b]quinolines
- Asymmetric syntheses of 1-Alkyltetrahydro-β-carbolines and a 9-Thio Analogue
- SYNTHESIS AND ANTITUMOR ACTIVITY OF 7-(N-GLYCOSYLAMINO)-INDOLO[3,2-b]QUINOLINES
- Asymmetric Synthesis of 1-Benzyltetrahydroisoquinolines Using Chiral Oxazolo[2,3-α]tetrahydro-isoquinolines
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives
- The Wittig Reaction of Benzofuran-2,3-diones
- Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners. I
- A Practical Synthetic Method for β-Ketoesters from Ketones
- One-Flask Synthesis of Sulfides from Alcohols and Alkyl Halides Using Benzoxazoline-2-thione
- A New Method for the Preparation of 2-Alkoxybenzoxazoles
- Synthesis of 3-Substituted Benzoxazoline-2-thiones
- Reaction of Benzoxazoline-2-thiones with Alkyl Halides
- Reaction of Anthranilamides with Levulinic Acids. Synthesis of 2,3,3a, 4-Tetrahydropyrrolo [2,1-b] quinazoline-1,9-diones
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. IV
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. III
- Reaction of 1,2,3,4-Tetrahydroquinazolin-4-ones with Acid Anhydride. II
- THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF TROPOLONE AND 8-HYDROXYQUINOLINE DERIVATIVES
- Polycyclic N-Hetero Compounds. VI. Synthesis of 11,13,15-Triazasteroidal Compounds and Correction of the Structures of Its Intermediates
- Syntheses of 3-Substituted 1-Methyl-6-phenylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H, 6H)-diones (6-Phenyl Analogs of Toxoflavin) and Their 4-Oxides, and Evaluation of Antimicrobial Activity of Toxoflavins and Their Analogs
- Condensation of Diethyl Acetonedicarboxylate. II
- Condensation of Diethyl Acetonedicarboxylate. I
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VI
- Polycyclic N-Hetero Compounds. XVI. Reactions of Benzyl Ketones with Formamide or Acetamide
- Benzylcarbonyl化合物とFormamideとの反応.VIII.m-位にMethyl基を有するα-Acylphenylacetonitrileの反応
- Polycyclic N-Hetero Compounds. VIII. Reactions of Ketones with Trisformylaminomethane
- Polycyclic N-Hetero Compounds. VII. Reactions of Benzyl Ketones with Formamide XI
- Reactivity of Isocoumarins. I. Effect of a Neighboring Hydroxyl Group on the Reduction of the Lactone Carbonyl Group
- Photochemical Reaction of Isocoumarin and Related Compounds
- Polycyclic N-Hetero Compounds. XVII. Reactions of Heterocyclic Active Methyl Group with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. XV. The Vilsmeier Reaction of Phenylacetonitriles. II
- Benzylcarbonyl化合物とFormamideとの反応(第9報)α-Acyl-5,6,7,8-tetrahydro-2-naphthylacetonitrileとの反応
- Benzylcarbonyl化合物とFormamideとの反応(第10報)α-Acyl-α-naphthylacetonitrileとの反応
- 1,3,10-Triazaphenanthreneの合成(第1報)
- Benzylcarbonyl化合物とFormamideとの反応(第7報) : Desoxybenzoinの反応
- Benzylcarbonyl化合物とFormamideとの反応(第6報) : Isoquinoline誘導体の生成
- Benzylcarbonyl化合物とFormamideとの反応(第5報) : α-Acyl-3,4-dimethoxyphenylacetonitrileとの反応
- Benzylcarbonyl化合物とFormamideとの反応(第4報)
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. IV.
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. III
- Diphenylethane系化合物の立体構造
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. IX
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VII
- Isocoumarin誘導体および関連化合物の呈する甘味と化学構造について(第5報)
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds
- Isocoumarin誘導体および関連化合物の呈する甘味と化学構造について(第4報)
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds. X. Syntheses of Sweet 5-Hydroxyflavanones and Related Dihydrochalcones
- Polycyclic N-Hetero Compounds. XIV. Reactions of Methylpyridines with Formamide
- Chemical Structure and Sweet Taste of Isocoumarins and Related Compounds Synthesis of 5-Hydroxyflavanones and Related Dihydrochalcones
- Polycyclic N-Hetero Compounds. XIII. Reactions of Pyridine N-Oxides with Formamide
- Chemical Structure and Sweet Taste of Isocoumarin and Related Compounds. VIII
- Polycyclic N-Hetero Compounds. XII. Reactions of Dihydroxynaphthalenes with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. XI. The Modified Vilsmeier Reaction of 4-Alkylpyrimidines
- Polycyclic N-Hetero Compounds. X. Reactions of 1,3-Cyclohexanedione and Its Dimer with Formamide or Trisformylaminomethane
- Polycyclic N-Hetero Compounds. IX. Reactions of Tetralones with Formamide or Trisformylaminomethane
- Synthesis and Structure-Activity Relationship of Spiro [isochroman-piperidine] Analogs for Inhibition of Histamine Release. II
- Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. II
- Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. I
- Synthesis and Biological Activity of Spiro [isocoumarin-piperidines] and Reltaed Compounds. I
- Polycyclic N-Hetero Compounds. V. A Novel Synthesis of Isoquinoline by the Vilsmeier Reaction of Phenylacetonitriles
- Polycyclic N-Hetero Compounds. III. Synthesis of 1,3,10-Triazaphenanthrenes
- Reactivity of Isocoumarins. IV. Reaction of 1-Ethoxyisochroman with Nucleophilic Reagents
- Condensation of Diethyl Acetonedicarboxylate. IV. Regioselective Reaction of Diethyl Acetonedicarboxylate-magnesium Complex
- Condensation of Diethyl Acetonedicarboxylate. III. Isolation and Acylation of Diethyl Acetonedicarboxylate-Magnesium Complex
- Synthesis of a Griseofulvin Analogue
- Reaction of Spiro[piperidine-4,2'-(1', 2', 3', 4'-tetrahydroquinazolin)]-4'-ones with Acid Anhydrides
- 生理活性を有するIsocoumarin誘導体の合成(第1報) : 3,4-Dihydroisocoumarin類の甘味と化学構造について
- Reactivity of Isocoumarins. III. Reaction of 1-Ethoxyisochroman with Benzylamines
- Reactivity of Isocoumarins. II. Reaction of 1-Ethoxyisochroman with Nucleophilic Reagents
- Synthesis of dl-Agrimonolide (Constituent of Rhizome of Agrimonia pilosa LEDEB)
- 生理活性を有するIsocoumarin誘導体の合成(第3報)3,4-Dihydroiso-coumarin類の甘味と化学構造について
- 生理活性を有するIsocoumarin誘導体の合成(第2報)3,4-Dihydroisocoumarin類の甘味と化学構造について
- Reactivity of Isocoumarins. V. Reaction of 1-Ethoxyisochroman with Active Methylene Compounds