生理活性を有するIsocoumarin誘導体の合成(第1報) : 3,4-Dihydroisocoumarin類の甘味と化学構造について

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概要

• 論文の詳細を見る

• The present studies were undertaken to elucidate the relationship between sweetness and chemical structure because of the interest of the structure of phyllodulcin, the only sweettasting compound among 3,4-dihydroisocoumarins. 3,4-Dihydroisocoumarin derivative, in which the 3'-hydroxy and 4'-methoxy groups bonded to the phenyl group in 3-position of phyllodulcin are present individually, had no sweetness. The presence of these hydroxyl and methoxyl in adjacent positions is necessary for the appearance of sweetness. Further, sweet taste is not found in the compound if the positions of these two groups are reversed. It was found by the syntheses of various derivatives that the lactone group and a hydroxyl group in 8-position did not take part in the appearance of sweet taste.

• 公益社団法人日本薬学会の論文
• 1972-04-25

著者

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 小山 鷹二

  岡山大学医学部付属病院薬剤部

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

• 芳田 典子

  第一薬科大学

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