Polycyclic N-Hetero Compounds. V. A Novel Synthesis of Isoquinoline by the Vilsmeier Reaction of Phenylacetonitriles

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概要

• 論文の詳細を見る

• A novel synthesis of 3-chloro-or 3-chloro-4-formylisoquinolines by the Vilsmeier reaction of phenylacetonitriles is described. 3,5-Dimethoxyphenylacetonitrile (I) afforded 3-chloro-6,8-dimethoxyisoquinoline (II) in a good yield and a small amount of 3-chloro-6,8-dimethoxy-4-formyl isoquinoline (III). Other phenylacetonitriles (V) afforded 3-chloro-4-formylisoquinoline derivatives (VI) only. The mechanism of this reaction is proposed.

• 公益社団法人日本薬学会の論文
• 1975-03-25

著者

• 大和 正利

  Faculty of Science, Okayama University of Science

• 小山 鷹二

  Faculty of Pharmaceutical Sciences, Medical School, Okayama University

• 大森 晋爾

  Faculty of Pharmaceutical Sciences, Medical School, Okayama University

• 廣田 喬

  Faculty Of Pharmaceutical Sciences Okayama University

• 大森 晋爾

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 篠原 百里江

  Faculty of Pharmaceutical Sciences, Medical School, Okayama University

• 篠原 百里江

  Faculty Of Pharmaceutical Sciences Medical School Okayama University

• 広田 喬

  岡山大学 薬

• 小山 鷹二

  Faculty Of Pharmaceutical Sciences Okayama University

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