Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. II

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概要

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• Numerous analogues of N-phenethyl-2-(isochroman-1-yl)-1-methylethylamine (3b), previously found to have inhibitory activity against aspirin-induced ulcer and no gastric antisecretory activity, were prepared and examined for gastric antisecretory activity and inhibitory activity against aspirin-induced ulcers in rats. It was found that a basic amine moiety is required for the antiulcer activity. Replacement of the isochroman ring of 3b by a thioisochroman, chroman, or tetralin ring resulted in a drastic change in the antiulcer activity. Among them, the chroman analogue N-phenethyl-2-(chroman-4-yl)-1-methylethylamine (32b) was found to have the most potent antiulcer activity, comparable with that of 3b.

• 公益社団法人日本薬学会の論文
• 1988-09-25

著者

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Science Okayama University Of Science

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 人見 進

  Faculty of Pharmaceutical Sciences, Okayama University

• 石川 維孝

  Faculty of Pharmaceutical Sciences, Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

• 石川 維孝

  Faculty Of Pharmaceutical Sciences Okayama University

• 人見 進

  Faculty Of Pharmaceutical Sciences Okayama University

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